摘要
微RNA-92a(microRNA-92a, miR-92a)是在进化中高度保守的致病微RNA,属于微RNA-17-92基因簇成员,参与调控细胞增殖、凋亡及分化等生物学活动。最近研究发现,miR-92a表达紊乱与疾病发生相关,主要通过调控靶基因或靶蛋白发挥致病作用。目前与miR-92a相关的研究主要集中在恶性肿瘤领域,且已发现其高表达与癌细胞恶性及肿瘤对放化疗敏感性降低相关。miR-92a靶向靶基因或靶蛋白致病及其与放化疗的关系,是近年来的研究热点。基于此,该文将miR-92a靶向靶基因或靶蛋白致病及其对化学治疗影响的最新研究进行了综述,以期对临床疾病诊疗提供靶标。
MicroRNA-92a(miR-92a)is an evolutionarily highly conserved pathogenic microRNA that is a member of the microRNA-17-92 gene cluster and is involved in the regulation of biological activities such as cell proliferation,apoptosis and differentiation.Recent studies have revealed that disorders of miR-92a expression are associated with disease development and exert pathogenic effects mainly through the regulation of target genes or target proteins.The current research related to miR-92a is mainly focused on malignant tumors,and its high expression has been found to be associated with cancer cell malignancy and reduced sensitivity of tumors to radiotherapy.miR-92a targeting target genes or target proteins to cause disease and its relationship with radiotherapy has been a hot research topic in recent years.Based on this,This article reviews the latest research on miR-92a target gene or target protein pathogenesis and its impact on chemotherapy in order to provide targets for clinical disease treatment.
作者
高自平
梁卫东
陈虎
司莹丽
杨博
GAO Ziping;LIANG Weidong;CHEN Hu;SI Yingli;YANG Bo(Department of Cardiothoracic Surgery,the First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,P.R.China;General Surgery Department,the second People's Hospital of Pengzhou,Pengzhou,Sichuan 611934,P.R.China;School of Clinical Medicine,Chengdu Medical College,Chengdu,Sichuan 610500,P.R.China)
出处
《华西医学》
CAS
2023年第6期930-937,共8页
West China Medical Journal
基金
成都市医学科研课题(2021078)
四川养老与老年健康协同创新中心科研项目(YLZBZ2019)。
关键词
靶基因
微RNA-92a
临床诊疗
靶标
Target gene
microRNA-92a
clinical diagnosis and treatment
target
