摘要
目的观察重症急性胰腺炎胃肠功能障碍患者实施早期目标导向集束化治疗的效果,进一步为患者的病情康复提供有效性、可行性方案。方法78例重症急性胰腺炎胃肠功能障碍患者作为研究对象,随机分为对照组及观察组,每组39例。对照组患者采用常规治疗,观察组患者采用早期目标导向集束化治疗。对比两组救治成功率,治疗前后的胃肠功能评分,不良事件发生率。结果观察组患者救治成功率为89.7%(35/39),高于对照组的71.8%(28/39),差异具有统计学意义(P<0.05)。治疗24、36、48 h后,观察组的胃肠功能评分分别为(7.6±0.6)、(6.4±0.5)、(6.1±0.6)分,均低于对照组的(10.4±1.1)、(9.5±1.2)、(8.1±1.2)分,差异具有统计学意义(P<0.05)。观察组不良事件发生率5.1%低于对照组的20.5%,差异具有统计学意义(P<0.05)。结论重症急性胰腺炎胃肠功能障碍患者采用早期目标导向集束化治疗,能够通过治疗方案改善肠蠕动,此外,结合不同的病期进行营养支持、腹压检测等,对胃肠道开展良性刺激,为改善胃肠道屏障功能做足了准备,对于患者的病情改善具有积极效用,有助于改善肠道功能,为患者的康复治疗提供了新方案。
Objective To observe the effect of early goal-directed bundle therapy for gastrointestinal dysfunction in patients with severe acute pancreatitis,so as to provide effective and feasible programs for patients'rehabilitation.Methods A total of 78 cases of severe acute pancreatitis with gastrointestinal dysfunction were randomly divided into control group and observation group,with 39 cases in each group.The control group received conventional treatment,and the observation group received early goal-directed bundle therapy.The success rate of treatment,gastrointestinal function score before and after treatment and the incidence of adverse events were compared between the two groups.Results The success rate of treatment in the observation group was 89.7%(35/39),which was higher than that of 71.8%(28/39)in the control group,and the difference was statistically significant(P<0.05).After 24,36 and 48 h treatment,the gastrointestinal function scores were(7.6±0.6),(6.4±0.5)and(6.1±0.6)points in the observation group,which were lower than those of(10.4±1.1),(9.5±1.2)and(8.1±1.2)points in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse events in the observation group was 5.1%,which was lower than that of 20.5%in the control group,and the difference was statistically significant(P<0.05).Conclusion Early goal-directed bundle therapy for the treatment of gastrointestinal dysfunction in patients with severe acute pancreatitis can improve intestinal peristalsis.In addition,nutritional support and abdominal pressure detection at different stages of disease can provide benign stimulation to the gastrointestinal tract,so as to make adequate preparation for improving the gastrointestinal barrier function.It has a positive effect on the improvement of the condition of patients,helps to improve the intestinal function,and provides a new regimen for the rehabilitation treatment of patients.
作者
张蕾
ZHANG Lei(Shenyang Jishuitan Hospital,Shenyang 110000,China)
出处
《中国实用医药》
2023年第11期172-174,共3页
China Practical Medicine
关键词
重症急性胰腺炎
胃肠功能障碍
早期目标导向集束化治疗
Severe acute pancreatitis
Gastrointestinal dysfunction
Early goal-directed bundle therapy
