摘要
目的比较2940 nm点阵铒激光联合点阵微等离子体射频(FMR)疗法与2940 nm点阵铒激光治疗萎缩性痤疮瘢痕的疗效及安全性。方法采用前瞻性随机对照研究方法。招募2018年3月—2021年3月就诊于上海交通大学医学院附属第九人民医院整复外科瘢痕激光门诊的符合入选标准的萎缩性痤疮瘢痕患者100例(男38例、女62例,年龄18~37岁),随机分为铒激光+FMR组及单纯铒激光组,每组50例。单纯铒激光组患者面部痤疮瘢痕采用2940 nm点阵铒激光进行治疗,铒激光+FMR组患者面部痤疮瘢痕除同前采用铒激光治疗外,还对U、M型瘢痕予FMR治疗,每3个月治疗1次,共治疗3次。首次治疗前及每次治疗后3个月,采用痤疮瘢痕临床评分量表(ECCA)进行瘢痕评分;观察并记录治疗过程中不良反应发生情况并计算发生率。末次治疗后3个月,采用5级分类法评价患者对治疗效果的满意情况并计算满意率。对数据行独立样本t检验、χ^(2)检验。结果最终89例患者完成试验,其中铒激光+FMR组46例[男19例、女27例,年龄(26±5)岁]、单纯铒激光组43例[男15例、女28例,年龄(27±6)岁]。2组患者首次治疗前及第1次治疗后3个月ECCA评分均相近(P>0.05)。铒激光+FMR组患者第2、3次治疗后3个月ECCA评分分别为(72±23)、(61±18)分,均明显低于单纯铒激光组的(85±26)、(76±25)分,t值分别为−2.45、−3.26,P<0.05。铒激光+FMR组和单纯铒激光组患者治疗过程中不良反应发生率分别为23.91%(11/46)、16.28%(7/43),组间比较差异无统计学意义(P>0.05)。末次治疗后3个月,铒激光+FMR组患者对治疗效果的满意率为78.26%(36/46),明显高于单纯铒激光组的53.49%(23/43),χ^(2)=6.10,P<0.05。结论2940 nm点阵铒激光联合FMR治疗面部萎缩性痤疮瘢痕的疗效显著优于单纯2940 nm点阵铒激光,且不会显著增加不良反应的发生率,患者对治疗效果的满意度更高,可作为推荐疗法应用于临床。
Objective To compare the efficacy and safety of 2940 nm fractional erbium laser combined with fractional micro-plasma radiofrequency(FMR)therapy and 2940 nm fractional erbium laser in the treatment of atrophic acne scars.Methods A prospective randomized controlled research was conducted.A total of 100 atrophic acne scar patients(38 males and 62 females,aged 18−37 years)who were treated in the Scar Laser Clinic of the Department of Plastic and Reconstructive Surgery of Shanghai Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine from March 2018 to March 2021 and conformed to the inclusion criteria were recruited.The patients were randomly divided into erbium laser+FMR group and erbium laser alone group,with 50 cases in each group.The facial acne scars of patients in erbium laser alone group were treated with 2940 nm fractional erbium laser,while the facial acne scars of patients in erbium laser+FMR group were treated with erbium laser as above,besides,the scars of U and M types were treated with FMR,once every 3 months for a total of 3 times.Before the first treatment and 3 months after each treatment,the Echelle D'Assessment Clinique des Cicatrices D'Acne(ECCA)was used to score the scar.The occurrence of adverse reaction during the treatment process was observed and recorded,and the incidence was calculated.Three months after the last treatment,the 5-level classification method was used to evaluate the satisfaction of patients with the treatment effect,and the satisfaction rate was calculated.Data were statistically analyzed with independent sample t test and chi-square test.Results A total of 89 patients completed the study,including 46 patients in erbium laser+FMR group(19 males and 27 females,aged(26±5)years)and 43 patients in erbium laser alone group(15 males and 28 females,aged(27±6)years).The ECCA scores before the first treatment and 3 months after the first treatment of patients were similar between the two groups(P>0.05).The ECCA scores of patients in erbium laser+FMR group at
作者
郭琪格
王棽
严敏
董继英
姚敏
Guo Qige;Wang Shen;Yan Min;Dong Jiying;Yao Min(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)
出处
《中华烧伤与创面修复杂志》
CAS
CSCD
北大核心
2023年第6期512-517,共6页
Chinese Journal of Burns And Wounds
基金
上海申康医院发展中心三年行动计划(SHDC2022CRT020)。
关键词
瘢痕
激光疗法
寻常痤疮
铒激光
微等离子体射频
Cicatrix
Laser therapy
Acne vulgaris
Erbium laser
Micro-plasma radiofrequency
