摘要
目的调查男性肥胖患者性激素水平及抑郁状态的发生率,分析两者与肥胖的关系。方法选取男性肥胖患者104例(肥胖组)及男性非肥胖受试者183例(对照组)。收集所有受试者一般临床资料[血压、身高、体重、BMI、腰臀比(WHR)]、实验室检查指标[血清性激素包括雌二醇(E2)、总睾酮(TT)、卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、孕酮(P)及空腹血糖(FPG)、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]及汉密尔顿抑郁量表(HAMD)评分并分组进行比较。采用Spearman相关分析评价HAMD评分与肥胖相关指标的相关性,采用二元logistic回归分析评估血清性激素水平、各肥胖相关因素及HAMD评分与肥胖的关系。结果肥胖组患者BMI、WHR、FINS、TG、TC、LDL-C、E2水平、HAMD评分及抑郁症患病率均高于对照组,而HDL-C水平及非抑郁状态发生率均低于对照组(P<0.05)。Spearman相关分析结果显示,男性肥胖患者HAMD评分与BMI、WHR、FINS、TC均呈显著正相关,E2水平与BMI、WHR、FPG、FINS、TC、TG、LDL-C、SDP、DBP均呈显著正相关;E2与HDL-C呈显著负相关,TT水平和TG呈显著负相关(P<0.05)。二元logistic回归分析结果显示,高E2、高TC及高LDL-C水平是肥胖的独立危险因素(P<0.05)。结论男性肥胖患者的E2水平及抑郁症患病率较高,抑郁症和肥胖呈正相关。
Objective To investigate the levels of sex hormones and incidence of depression in obese male patients,and to analyze the relationship between sex hormones and depression with obesity.Methods A total of 104 male obese patients(obesity group)and 183 male non-obese subjects(control group)were selected.The general clinical data of all subjects[blood pressure,height,weight,BMI,waisthip ratio(WHR)],laboratory examination indexes[serum sex hormones including estradiol(E2),total testosterone(TT),follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),progesterone(P),fasting plasma glucose(FPG),Fasting insulin(FINS),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)] and Hamilton depression scale(HAMD)score were collected and compared in groups.Spearman correlation analysis was used to evaluate the correlation between HAMD score and obesity related indicators.Binary logistic regression analysis was used to evaluate the relationship between serum sex hormone levels,Various obesity-related factors and HAMD score with obese.Results The BMI,WHR,FINS,TG,TC,LDL-C,E2,prevalence of depression and HAMD score of the obese group were higher than those in the control group,while the HDL-C level and incidence of non-depressive state were lower than those in the control group(P<0.05).Spearman correlation analysis showed that HAMD score was significantly positively correlated with BMI,WHR,FINS and TC in male obese patients,and E2 level was significantly positively correlated with BMI,WHR,FPG,FINS,TC,TG,LDL-C,SDP and DBP.The level of E2 was significantly negatively correlated with HDL-C,and the level of TT was significantly negatively correlated with TG(P<0.05).Binary logistic regression analysis showed that high E2,TC and LDL-C levels were independent risk factors for obesity(P<0.05).Conclusion The level of E2 and the prevalence of depression are higher in male obese patients,and depression is positively correlated with obesity.
作者
季业
包玉倩
庄新娟
田海荣
刘振
Ji Ye;Bao Yuqian;Zhuang Xinjuan;Tian Hairong;Liu Zhen(Department of Endocrinology and Metabolism,Jinshan Branch of Shanghai Sixth People's Hospital,Shanghai 201599,China;不详)
出处
《临床内科杂志》
CAS
2023年第5期318-321,共4页
Journal of Clinical Internal Medicine
基金
上海市金山区医药卫生类科技创新资金资助项目(2018311)。
关键词
抑郁症
抑郁状态
肥胖
雌二醇
总睾酮
Depression
State of depression
Obesity
Estradiol
Total testosterone
