摘要
目的:观察银杏二萜内酯葡胺注射液联合阿替普酶静脉溶栓治疗老年急性脑梗死(ACI)患者的效果。方法:选取2020年1月至2022年11月该院收治的98例老年ACI患者进行前瞻性研究,按随机数字表法将其分为对照组和观察组各49例。对照组采用阿替普酶静脉溶栓治疗,观察组在对照组基础上联合银杏二萜内酯葡胺注射液治疗。比较两组临床疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分、大脑中动脉血流速度[舒张末期血流速度(EDV)、收缩期峰值流速(PSV)、平均血流速度(Vm)]、血清细胞因子[3-巯基丙酮酸硫基转移酶(3-MST)、中枢神经特异性蛋白(S100β)、泛连接蛋白1(PANX1)、神经元特异性烯醇化酶(NSE)]水平,以及不良反应发生率。结果:观察组治疗总有效率为93.88%(46/49),高于对照组的79.59%(39/49),差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分低于对照组,BI评分高于对照组,差异均有统计学意义(P<0.05);观察组大脑中动脉EDV、PSV、Vm和血清3-MST水平均高于对照组,血清S100β、NSE、PANX1水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏二萜内酯葡胺注射液联合阿替普酶静脉溶栓治疗老年ACI患者可提高治疗总有效率、BI评分和大脑中动脉血流速度,改善血清细胞因子水平,以及降低NIHSS评分,效果优于单纯阿替普酶静脉溶栓治疗。
Objective:To observe effects of Ginkgo diterpene lactone meglumine injection combined with Alteplase intravenous thrombolysis in treatment of elderly patients with acute cerebral infarction(ACI).Methods:A prospective study was conducted on 98 elderly ACI patients admitted to the hospital from January 2020 to November 2022.They were divided into control group and observation group according to the random number table method,49 cases in each.The control group was treated with Alteplase intravenous thrombolysis,while the observation group was treated with Ginkgo diterpene lactone meglumine injection on the basis of that of the control group.The clinical efficacy,the National Institutes of Health Stroke Scale(NIHSS)score,the Barthel Index(BI)score,the middle cerebral artery blood flow velocity[end-diastolic blood flow velocity(EDV),peak systolic blood flow velocity(PSV),mean blood flow velocity(Vm)],the serum cytokine levels[3-mercaptopyruvate sulfur transferase(3-MST),central nervous specific protein(S100β),pannexin1(PANX1),neuron-specific enolase(NSE)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.88%(46/49),which was higher than 79.59%(39/49)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score of the observation group was lower than that of the control group,the BI score was higher than that of the control group,and the differences were statistically significant(P<0.05).The levels of middle cerebral artery EDV,PSV,Vm and the serum 3-MST in the observation group were higher than those in the control group,the levels of serum S100β,NSE and PANX1 were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ginkgo diterpene lactone meglumine injection
作者
梁冰
杨凯
宋明辉
LIANG Bing;YANG Kai;SONG Minghui(Department of Pharmacy of No.990 Hospital of Joint Logistics Support Force,Zhumadian 463000 Henan,China)
出处
《中国民康医学》
2023年第10期102-105,共4页
Medical Journal of Chinese People’s Health
关键词
银杏二萜内酯葡胺注射液
阿替普酶
静脉溶栓
老年
急性脑梗死
神经功能缺损
血流速度
Ginkgo diterpene lactone meglumine injection
Alteplase
Intravenous thrombolysis
Elderly
Acute cerebral infarction
Neurological deficit
Blood flow velocity
