摘要
目的:观察枯草杆菌二联活菌颗粒联合四联疗法治疗幽门螺杆菌(Hp)阳性十二指肠球部溃疡患者的效果。方法:选取2020年2月至2022年2月该院收治的137例Hp阳性十二指肠球部溃疡患者进行前瞻性研究,按随机数字表法将其分为对照组68例和观察组69例。对照组采用四联疗法治疗,观察组在对照组基础上联合枯草杆菌二联活菌颗粒治疗。比较两组治疗前后胃功能指标[胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃蛋白酶原比值(PGR)]水平、临床疗效、Hp根除率及不良反应发生率。结果:治疗后,两组PGⅠ、PGⅡ水平和PGR均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为98.55%(68/69),高于对照组的88.24%(60/68),差异有统计学意义(P<0.05);治疗后4周,观察组Hp根除率为94.20%(65/69),高于对照组的79.41%(54/68),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:枯草杆菌二联活菌颗粒联合四联疗法治疗Hp阳性十二指肠球部溃疡患者可降低胃蛋白酶原水平,提高治疗总有效率和Hp根除率,效果优于单纯四联疗法。
Objective:To observe effects of combined Bacillus subtilis and Enterococcus faecium granules with multivitamines,live combined with quadruple therapy in treatment of Helicobacter pylori(Hp)-positive duodenal ampulla ulcer.Methods:A prospective study was conducted on 137 patients with Hp-positive duodenal ulcer admitted to this hospital from February 2020 to February 2022.They were divided into control group(68 cases)and observation group(69 cases)according to the random number table method.The control group was treated with quadruple therapy,while the observation group was treated with combined Bacillus subtilis and Enterococcus faecium granules with multivitamines,live on the basis of that of the control group.The levels of gastric function indexes[pepsinogen I(PGI),pepsinogen II(PGII),pepsinogen ratio(PGR)],the clinical efficacy,the Hp eradication rate,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of PGI,PGII and PGR in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 98.55%(68/69),which was higher than 88.24%(60/68)in the control group,and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the Hp eradication rate in the observation group was 94.20%(65/69),which was higher than 79.41%(54/68)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Combined Bacillus subtilis and Enterococcus faecium granules with multivitamines,live combined with quadruple therapy can reduce the level of pepsinogen,improve the total effective rate and the Hp eradication rate in the treatment of Hp-positive duodenal ampulla ulcer.Moreover,it is superior to
作者
吴加良
WU Jialiang(Emergency Department of the People’s Hospital of Yugan,Shangrao 335100 Jiangxi,China)
出处
《中国民康医学》
2023年第9期50-52,共3页
Medical Journal of Chinese People’s Health
关键词
十二指肠球部溃疡
幽门螺杆菌
枯草杆菌二联活菌颗粒
四联疗法
胃泌素
胃蛋白酶原
不良反应
Duodenal ampulla ulcer
Helicobacter pylori
Combined Bacillus subtilis and Enterococcus faecium granules with multivitamines,live
Quadruple therapy
Gastrin
Pepsinogen
Adverse reaction
