摘要
目的观察非小细胞肺癌骨转移患者予以多维度协同管理和化疗、唑来膦酸联合干预对其生活质量、疼痛程度、临床效果的影响。方法临床纳入2021年7月至2022年7月河南大学第一附属医院收治的80例非小细胞肺癌骨转移患者,根据随机双盲法分组,分为对照组、研究组,每组均为40例,研究组予以多维度协同管理和化疗、唑来膦酸联合干预,对照组予以多维度协同管理和化疗干预。应用肿瘤患者生存治疗量表分析评估(QLQ-C30)分析两组的生活质量;分析两组的临床效果、心理状况、生活质量、不良反应。结果研究组的临床治疗效果优于对照组,差异有统计学意义(P<0.05)。干预后两组不良心理状态(抑郁、焦虑)指标评分低于干预前,且研究组不良心理(抑郁、焦虑)指标评分低于对照组,差异有统计学意义(P<0.05)。干预后两组肿瘤患者QLQ-C30评分指标均高于干预前,且研究组肿瘤患者QLQ-C30评分指标高于对照组,差异有统计学意义(P<0.05)。治疗后两组不良反应(皮疹、肌痛、发热、恶心呕吐)发生情况比较,差异无统计学意义(P>0.05)。结论非小细胞肺癌骨转移予以多维度协同管理联合化疗、唑来膦酸联合干预可提高患者的心理状态,治疗效果显著,治疗安全性较高,可提高其生活质量,值得临床应用。
Objective To observe the influence of multi-dimensional collaborative management,chemotherapy and zoledronic acid on the life quality,pain degree and treatment effects for non-small cell lung cancer patients with osseous metastasis.Methods A total of 80 non-small cell lung cancer patients with osseous metastasis treated from July 2021 to July 2022 in the First Affiliated Hospital of Henan University were selected.According to random double-blind method,patients were divided into control group and study group,with 40 cases in each group.The study group was given multi-dimensional collaborative management and combined intervention of chemotherapy and zoledronic acid,while the control group was given multi-dimensional collaborative management and chemotherapy intervention.Patient’s life quality was appraised through the quality of life questionnaire core 30(QLQ-C30).Analyze the clinical effects,psychological status,life quality,and adverse reactions of the two groups.Results The clinical effects in the study group were better than control group,with statistically significant difference(P<0.05);after intervention,the adverse mental state scores of depression and anxiety for two groups were remarkably decreased;the adverse mental state scores in the study group were even lower than control group,with statistically significant difference(P<0.05);after treatment,QLQ-C30 scores of social function,emotional function,cognitive function,role physical and physical function for two groups were remarkably increased;QLQ-C30 scores of social function,emotional function,cognitive function,role physical and physical function in the study group were even higher than control group,with statistically significant difference(P<0.05);the incidences of adverse reactions like skin rash,myalgia,fever,nausea and vomiting in the study group were lower than control group,with statistically significant difference(P<0.05).Conclusion The multi-dimensional collaborative management,chemotherapy and zoledronic acid can effectively improve the men
作者
徐春红
王丹
王峻
张悦华
XU Chunhong;WANG Dan;WANG Jun;ZHANG Yuehua(Department of Pain,the First Affiliated Hospital of Henan University,Kaifeng Henan 475000,China;Department of Fourth Psychiatry,Luoyang Fifth People’s Hospital,Luoyang Henan 471000,China;Department of Equipment,Kaifeng Rehabilitation Hospital,Kaifeng Henan 475000,China;Department of Oncology,First Affiliated Hospital of Henan University,Kaifeng Henan 475000,China)
出处
《临床研究》
2023年第7期69-72,共4页
Clinical Research
基金
河南省医学科技攻关计划(联合共建)项目(LHGJ20190500)。
关键词
生活质量
疼痛程度
骨转移
非小细胞肺癌
多维度协同管理
唑来膦酸
life quality
pain degree
osseous metastasis
non-small cell lung cancer
multi-dimensional collaborative management
zoledronic acid
