摘要
目的探究θ短阵快速脉冲刺激(TBS)模式下高频重复经颅磁刺激(rTMS)辅助治疗慢性精神分裂症的效果。方法前瞻性选取2021年5月至2022年5月合肥市第四人民医院收治的98例慢性精神分裂症患者作为研究对象,采用随机数字表法分为两组:对照组、试验组,各49例。其中对照组给予伪刺激,试验组给予TBS模式下高频rTMS辅助治疗,疗程4周。比较两组患者病情及症状改善情况、社会功能、认知功能、不良反应。结果治疗后,对照组简明精神病评定量表(BPRS)评分较治疗前比较,差异无统计学意义(P>0.05),试验组BPRS评分较治疗前下降,试验组BPRS评分为(31.26±1.77)分,低于对照组[(32.38±1.86)分],差异有统计学意义(P<0.05)。两组治疗后一般精神病理症状评分、阳性症状评分比较,差异均无统计学意义(P>0.05),试验组阴性症状、总分评分分别为(13.22±2.39)、(60.86±6.07)分,低于对照组[(16.18±2.54)、(64.87±6.14)分],差异均有统计学意义(P<0.05)。两组治疗前及治疗后社会适应能力评定量表(SAFE)评分比较,差异均无统计学意义(P>0.05)。对照组治疗后MDRS-2评分与治疗前比较,差异无统计学意义(P>0.05),试验组治疗后MDRS-2评分升高,且高于对照组,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用TBS模式下高频rTMS辅助治疗可显著改善慢性精神分裂症患者的病情及症状、认知功能,但对于患者社会功能的改善效果不显著。
Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation(rTMS)under theta burst stimulation(TBS)mode in treating chronic schizophrenia.Methods A total of 98 patients with chronic schizophrenia admitted to Hefei Fourth People’s Hospital from May 2021 to May 2022 were selected as the research objects,and randomly divided into control group and experimental group according to the random number table,with 49 cases in each group.The control group was given pseudo stimulation,and the experimental group was given high-frequency rTMS adjuvant treatment in TBS mode,for 4 weeks.The conditions,symptoms improvement,social function,cognitive function and adverse reactions were compared between the two groups.Results After treatment,there was no statistically significant difference in the BPRS score of the control group compared to that before treatment(P>0.05);the BPRS score of the experimental group decreased compared to that before treatment,the BPRS score of the experimental group was(31.26±1.77)points,which was lower than that of the control group[(32.38±1.86)points],the difference was statistically significant(P<0.05).After treatment,there were no statistically significant differences between the two groups in the scores of general psychopathological symptoms and positive symptoms(P>0.05);the scores of negative symptoms and total scores in the experimental group were(13.22±2.39),(60.86±6.07)points,which were lower than those in the control group[(16.18±2.54),(64.87±6.14)points],the differences were statistically significant(P<0.05).There were no statistically significant differences in the social adaptive functioning evaluation(SAFE)scores of the two groups before and after treatment(P>0.05).There was no statistically significant difference in MDRS-2 scores of the control group before and after treatment(P>0.05);after treatment,MDRS-2 score in experimental group was increased,was higher than that in control group,the difference was statistically significant(P<0.05).There
作者
李丽
陈学全
费龙才
LI Li;CHEN Xue-quan;FEI Long-cai(Department of Psychiatry,Anhui Mental Health Center,Hefei Fourth People’s Hospital,Hefei Anhui 230032,China)
出处
《临床和实验医学杂志》
2023年第9期938-941,共4页
Journal of Clinical and Experimental Medicine
基金
国家自然科学基金青年基金(编号:31800909)。
关键词
慢性精神分裂症
θ短阵快速脉冲刺激
高频重复经颅磁刺激
Chronic schizophrenia
Theta burst stimulation
High-frequency repetitive transcranial magnetic stimulation
