摘要
目的掌握2019—2022年株洲市手足口病流行病学和病原学特征,为制订更加科学、有效的手足口病防控策略提供依据。方法通过中国疾病预防控制中心传染病报告信息管理系统选取18801份株洲市2019—2022年所有手足口病报告信息,采用描述性流行病学方法分析其流行病学特征;根据湖南省手足口监测方案采集临床诊断为手足口病的典型病例粪便或咽拭子样本,用实时荧光定量PCR方法进行肠道病毒通用(EV)型、EV71型、CoxA16型的核酸检测,并对结果进行病原学分析。结果株洲市2019—2022年累计报告手足口病病例18801例,年均报告发病率121/10万。2486例手足口病实验室病例样本检测,肠道病毒核酸阳性1586例,检出率63.8%。其中其他型肠道病毒732例,占阳性病例总数的46.2%。男女性别比例为1.24∶1。从年龄分布来看,1~2岁年临段病例数最多,占25.9%(4866/18801),其次分别为3~4岁年龄组,占20.9%(3931/18801),2~3岁年龄组,占18.2%(3426/18801)。结论2019—2022年株洲市手足口病病原体主要是其他型肠道病毒,而EV71毒株具有明显升高趋势,应加强手足口病病病原监测,及时掌握病原分布及变化情况,并适时地调整手足口病的防控措施。
Objective To grasp the epidemiological and pathogenic characteristics of hand,foot and mouth disease in Zhuzhou City from 2019 to 2022,so as to provide a basis for the development of more scientific and effective prevention and control strategies for hand-foot-and-mouth disease.Methods The epidemiological characteristics of all Hand,foot and mouth disease reports in Zhuzhou City from 2019 to 2022 were analyzed by descriptive epidemiological methods through the Chinese Center for Disease Control and Prevention Infectious Disease Reporting Information Management System by selecting 18801 reports of Hand,foot and mouth disease in Zhuzhou City.Stool or pharyngeal swab samples from typical cases clinically diagnosed with Hand,foot and mouth disease were collected according to the Hunan Provincial Hand,foot and mouth disease Surveillance Program,and nucleic acid tests for enterovirus general(EV)type,EV71 type,and CoxA16 type were performed by Real time fluorescence quantitative PCR,and the results were analyzed pathogenetically.Results A cumulative total of 18801 Hand,foot and mouth disease cases were reported in Zhuzhou City from 2019 to 2022,with an average annual reported incidence rate of 121/100000.2486 Hand,foot and mouth disease laboratory case samples were tested,and 1586 cases were positive for enterovirus nucleic acid,with a detection rate of 63.8%.Among them,732 cases were other types of enteroviruses,accounting for 46.2%of the total positive cases.The male to female sex ratio was 1.24∶1.From the perspective of age distribution,the number of temporary cases in the 1-2 year old age group is the highest,accounting for 25.9%(4866/18801),followed by the 3-4 year old age group,accounting for 20.9%(3931/18801),and the 2-3 year old age group,accounting for 18.2%(3426/18801).Conclusion The pathogens of Hand,foot and mouth disease in Zhuzhou City from 2019 to 2022 are mainly other types of enteroviruses,while EV71 strains have a significantly higher trend,and Hand,foot and mouth disease pathogen surveillance should
作者
贺放晴
胡丹
李嘉倩
罗誉皓
HE Fangqing;HU Dan;LI Jiaqian;LUO Yuhao(Zhuzhou Center for Disease Prevention and Control,Zhuzhou,Hunan Province,412000 China)
出处
《中国卫生产业》
2023年第6期196-199,共4页
China Health Industry
关键词
手足口病
病原学特征
流行病学特征
Hand-foot-and-mouth disease
Etiological characteristics
Epidemiological characteristics
