摘要
Gastric and esophageal cancers are multifactorial and multistage-involved malignancy.While the impact of gut microbiota on overall human health and diseases has been well documented,the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear.This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions,and the potential role of dysbiosis in carcinogenesis and tumorigenesis.This review will also discuss how dysbiosis stimulates local and systemic immunity,which may impact on the immunotherapy for cancer.
胃癌和食管癌的发生是多因素多阶段的。尽管肠道菌群对人体健康和疾病的影响已广为报道,但胃/食管菌群对于胃癌和食管癌的影响仍不明了。本文综述了胃/食管菌群在正常生理及病理状态下的组成变化,以及菌群失调在肿瘤发生中的潜在作用。同时还探讨了胃/食管菌群失调是如何刺激局部及全身免疫,从而影响胃癌和食管癌的免疫治疗。
基金
supported by the Comprehensive Cancer Center Support Grant of the Ohio State University as part from the National Institutes of Health P30 CA16058-32(to X.Z.)
R01 CA185055 from the National Cancer Institute
S10 OD025230 from the National Heart,Lung,and Blood Institute(to Z.P.).
