摘要
目的:探讨保乳手术对早期乳腺癌患者围手术期指标及血清肿瘤标志物的影响。方法:选取贵阳市妇幼保健院2020年10月—2021年10月收治的102例早期乳腺癌患者为研究对象,根据随机数表法分为两组,各51例。观察组采用保乳手术治疗,对照组采用改良根治术治疗,比较两组围手术期指标及血清肿瘤标志物、美容效果、生命质量。结果:观察组最大手术切缘(15.96±2.08)mm、最小手术切缘(9.07±1.22)mm、切除体积(63.52±6.33)mL均小于对照组,术中出血量(323.49±20.33)mL、术后引流量(178.91±17.20)mL均少于对照组,手术时间(162.06±16.30)min短于对照组,差异有统计学意义(P<0.05);术后1年,观察组血清肿瘤标志物糖类抗原15-3(CA15-3)(27.49±2.34)U/mL、癌胚抗原(CEA)(5.03±1.22)μg/mL、糖类抗原125(CA125)(18.60±2.08)U/mL水平低于对照组,差异有统计学意义(P<0.05);观察组术后美容效果优于对照组,差异有统计学意义(P<0.05);术后1年,观察组乳腺癌患者生命质量测定量表(FACT-B)中文版各领域评分均高于对照组,差异有统计学意义(P<0.05)。结论:保乳手术治疗早期乳腺癌患者相较于改良根治术可减轻损伤,改善血清肿瘤标志物水平,且能提升术后乳房美容效果及生命质量。
Objective:To investigate the effect of breast conserving surgery on perioperative indexes and serum tumor markers in patients with early-stage breast cancer.Method:A total of 102 patients with early-stage breast cancer who were admitted to Guiyang Maternal and Child Health Care Hospital from October 2020 to October 2021 were selected as the research objects,and they were divided into two groups according to random number table,51 cases in each group.The observation group received breast conserving surgery,while the control group received modified radical surgery.The perioperative indicators,serum tumor markers,cosmetic effects,and quality of life were compared between the two groups.Result:The maximum surgical margin of(15.96±2.08)mm,minimum surgical margin of(9.07±1.22)mm,and resection volume of(63.52±6.33)mL in the observation group were smaller than those in the control group,the intraoperative bleeding volume of(323.49±20.33)mL,postoperative drainage volume of(178.91±17.20)mL were less than those in the control group,and the surgical time of(162.06±16.30)min was shorter than that in the control group,the differences were statistically significant(P<0.05).One year after surgery,the observation group had serum tumor markers such as carbohydrate antigen 15-3(CA15-3)of(27.49±2.34)U/mL,carcinoembryonic antigen(CEA)of(5.03±1.22)μg/mL,carbohydrate antigen 125(CA125)of(18.60±2.08)U/mL were lower than those of the control group,the differences were statistically significant(P<0.05).The observation group had better postoperative cosmetic effects than the control group,the difference was statistically significant(P<0.05).One year after surgery,the scores of the Chinese version of the breast cancer patients'quality of life scale(FACT-B)in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Compared with modified radical mastectomy,breast conserving surgery for early-stage breast cancer patients can reduce the damage,improve the leve
作者
邹佳黎
吴培新
杨毅
杨志欣
ZOU Jiali;WU Peixin;YANG Yi;YANG Zhixin(Guiyang Maternal and Child Health Care Hospital,Guiyang 550003,China;不详)
出处
《中外医学研究》
2023年第16期5-8,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
贵阳市科技计划项目(筑科合同[2022]-4-11号)。
关键词
早期乳腺癌
保乳手术
围手术期指标
肿瘤标志物
Early-stage breast cancer
Breast conserving surgery
Perioperative indicators
Tumor markers
