摘要
【目的】探讨复方苦参注射液联合化疗药对胃癌患者术后免疫功能及血清癌胚抗原(CEA)、糖类抗原(CA)水平的影响。【方法】将92例胃癌根治术后患者随机分为治疗组和对照组,每组各46例。对照组患者术后2周后开始化疗(卡培他滨+奥沙利铂),治疗组在对照组的基础上加用复方苦参注射液静脉滴注治疗,21 d为1个疗程,连续治疗3个疗程。观察2组患者治疗前后中医证候积分、T淋巴细胞亚群CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平及血清CEA、CA72-4、CA19-9水平的变化情况,并比较2组患者的不良反应发生情况。【结果】(1)中医证候方面,治疗后,2组患者的中医证候积分均较治疗前明显降低(P<0.05),且治疗组的降低作用明显优于对照组(P<0.01)。(2)免疫功能方面,治疗后,治疗组的T淋巴细胞亚群CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平较治疗前明显升高(P<0.05),CD8^(+)水平较治疗前明显降低(P<0.05),而对照组均无显著性变化(P>0.05),组间比较,治疗组对CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平的升高作用及对CD8^(+)水平的降低作用均明显优于对照组(P<0.05)。(3)肿瘤标志物方面,治疗后,2组患者的血清CEA、CA72-4及CA19-9水平均较治疗前明显降低(P<0.05),且治疗组对血清CEA、CA72-4及CA19-9水平的降低作用均明显优于对照组(P<0.05)。(4)不良反应方面,治疗后,治疗组的白细胞计数降低、血小板计数降低及转氨酶升高的发生率均低于对照组(P<0.05或P<0.01);而2组患者的血红蛋白降低、恶心呕吐、腹泻、口腔炎及神经毒性发生率比较,差异均无统计学意义(P>0.05)。【结论】复方苦参注射液联合化疗药物治疗胃癌术后患者,可有效改善患者临床症状,提高患者的免疫功能,降低血清肿瘤标志物水平,减少胃癌患者术后化疗不良反应的发生。
Objective To investigate the effects of Compound Kushen Injection combined with chemotherapeutic agents on postoperative immune function and serum carcinoembryonic antigen(CEA)and carbohydrate antigen(CA)levels in patients with gastric cancer.Methods Ninety-two patients after radical surgery for gastric cancer were randomly divided into the treatment and the control groups,with 46 patients in each group.Patients in the control group started chemotherapy(capecitabine+oxaliplatin)2 weeks after surgery,while the treatment group was treated with Compound Kushen Injection intravenously on the basis of the treatment of the control group.Both groups of patients were treated for 3 consecutive courses and 21 days constituted a course of treatment.The changes in the traditional Chinese medicine(TCM)syndrome scores,the levels of T-lymphocyte subsets CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+),and serum levels of CEA,CA72-4 and CA19-9 in the two groups were observed before and after treatment,and the incidence of adverse reactions was compared between the two groups.Results(1)After treatment,the TCM syndrome scores of both groups were significantly decreased in comparison with those before treatment(P<0.05),and the effect on lowering the scores in the treatment group was significantly superior to that in the control group(P<0.01).(2)After treatment,the levels of T lymphocyte subsets CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the treatment group were significantly increased(P<0.05),and CD8^(+)level was significantly decreased compared with that before treatment(P<0.05),while none of the immune function indicators in the control groups showed significant changes before and after treatment(P>0.05).The intergroup comparison showed that the treatment group had stronger effect on increasing the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and on decreasing the CD8^(+)level than the control group(P<0.05).(3)After treatment,serum levels of tumor markers CEA,CA72-4 and CA19-9 in the two groups were significantly decreased compared with those be
作者
郜娜娜
贺新爱
马馨
GAO Na-Na;HE Xin-Ai;MA Xin(Dept.of General Medicine,Jiaozuo Second People’s Hospital,Jiaozuo 454000 Henan,China)
出处
《广州中医药大学学报》
CAS
2023年第5期1104-1109,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
河南省医学科技攻关计划联合共建项目(编号:LHGJ20191336)。
关键词
复方苦参注射液
胃癌根治术后
免疫功能
癌胚抗原
糖类抗原72-4
糖类抗原19-9
不良反应
Compound Kushen Injection
radical operation for gastric cancer
immune function
carcinoembryonic antigen
carbohydrate antigen 72-4(CA72-4)
carbohydrate antigen 19-9(CA19-9)
adverse reaction
