摘要
【目的】观察加味当归四逆汤联合温针灸治疗寒湿凝滞型慢性盆腔炎性后遗症(SPID)的临床疗效。【方法】将70例寒湿凝滞型慢性SPID患者随机分为观察组和对照组,每组各35例,对照组给予西药常规治疗,观察组在对照组治疗的基础上,给予加味当归四逆汤联合温针灸治疗,均连续治疗40 d。治疗40 d后,评价2组临床疗效,观察2组患者治疗前后中医证候积分、视觉模拟量表(VAS)评分的变化情况,以及肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)和白细胞介素10(IL-10)水平的情况。比较2组患者治疗前后血浆黏度和红细胞压积的变化情况。并评价2组的复发率及不良反应的发生情况。【结果】(1)观察组总有效率为91.43%(32/35),对照组为71.43%(25/35)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的中医证候积分与VAS评分均明显改善(P<0.05),且观察组在改善中医证候积分与VAS评分方面均明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的TNF-α、IL-6、IL-8、IL-10水平均明显改善(P<0.05),且观察组在改善TNF-α、IL-6、IL-8、IL-10水平方面明显优于对照组,差异均有统计学意义(P<0.05)。(4)治疗后,2组患者的血浆黏度、红细胞压积均明显改善(P<0.05),且观察组在改善血浆黏度、红细胞压积方面明显优于对照组,差异均有统计学意义(P<0.05)。(5)观察组复发率为2.86%(1/35),对照组为22.86%(8/35)。观察组复发率明显低于对照组,差异有统计学意义(P<0.05)。(6)观察组不良反应发生率为11.43%(4/35);对照组为8.57%(3/35),2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】加味当归四逆汤联合温针灸治疗寒湿凝滞型慢性盆腔炎性后遗症,能明显改善患者的血液循环及临床症状,复发率低,临床效果显著。
Objective To observe the clinical efficacy of modified Danggui Sini Decoction combined with warmingneedle moxibustion on the treatment of sequela of chronic pelvic inflammatory disease(SPID)of cold-damp stagnation type.Methods Seventy patients with chronic SPID of cold-damp stagnation type were randomly divided into the observation group and the control group,with 35 patients in each group.The control group was given conventional western medicine treatment,while the observation group was additionally treated with modified Danggui Sihui Decoction combined with warming-needle moxibustion on top of the control group.After 40 days of treatment,the clinical efficacy of the two groups was evaluated,and the changes in the traditional Chinese medicine(TCM)syndrome score,visual analogue scale(VAS)score,and the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-10(IL-10)were observed before and after treatment.The changes in plasma viscosity and red blood cell pressure in the two groups were compared before and after treatment.The recurrence rate and the occurrence of adverse reactions in the two groups were evaluated.Results(1)The total effective rate of the observation group was 91.43%(32/35)and that of the control group was 71.43%(25/35).The efficacy of the observation group was superior to that of the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the TCM syndrome score and VAS score of patients in both groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving both the TCM syndrome score and VAS score,and the difference was statistically significant(P<0.05).(3)After treatment,the levels of TNF-α,IL-6,IL-8 and IL-10 in both groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving the levels of TNF-α,IL-6,IL-8 and IL-10,and the difference was statistically significant(P<0.05).(4)After tre
作者
方菲
张素娟
高倩
刘昊
马莹
汪洁
FANG Fei;ZHANG Su-Juan;GAO Qian;LIU Hao;MA Ying;WANG Jie(Dept.of Gynecology,Baoding Second Central Hospital,Baoding 072750 Hebei,China;Outpatient Department,Baoding No.1 Central Hospital,Baoding 071000 Hebei,China;Dept.of Obstetrics,Baoding Second Central Hospital,Baoding 072750 Hebei,China)
出处
《广州中医药大学学报》
CAS
2023年第6期1382-1388,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
保定市科技计划资助项目(编号:2041ZF223)。
关键词
加味当归四逆汤
温针灸
盆腔炎性后遗症
寒湿凝滞型
中医证候
细胞因子
modified Danggui Sini Decoction
warming-needle moxibustion
sequela of pelvic inflammatory disease(SPID)
TCM syndrome
cytokine
