摘要
目的了解某医院药品不良反应的发生特点及规律,为临床安全合理用药提供参考依据。方法收集医院2017年1月-2021年12月上报的药品不良反应报告,回顾性分析患者性别、年龄、给药途径、药品种类、累及系统/器官及转归情况。结果(1)867例药品不良反应报告中,药品不良反应发生最多的类型是已知一般674例(77.74%);(2)男性528例(60.90%),女性339例(39.10%),45~64岁患者最多(506例,58.36%);(3)药品不良反应涉及的给药途径中静脉滴注发生率最高(664例,76.23%);(4)药品不良反应涉及的药品种类中造影剂最多(171例,19.63%),抗肿瘤药物、肝胆治疗药物及抗菌药物分别为第2和第3位;(5)药品不良反应累及系统/器官以皮肤及皮下组织最多(407例,38.61%);(6)多数患者经治疗后可痊愈(847例,97.69%)。结论药品不良反应的发生可能与患者性别、年龄、给药途径、药品种类等多种因素相关,临床医务人员应重视药品不良反应监测和上报工作,以更好地保障安全、合理用药。
Objective To find out about the incidence,characteristics and regularity of adverse drug reactions(ADRs)in a hospital so as to provide reference for clinical rational drug use.Methods ADR reports submitted by the hospital between January 2017 and December 2021 were collected.The gender,age,routes of administration,types of drugs,systems/organs involved,and outcomes were retrospectively analyzed.Results(1)Among the 867 reports of ADRs,the most common ADRs were ordinary cases(674,77.74%).(2)The number of male patients was(528,60.90%),compared with(339,39.10%)for females.ADRs occurred most frequently in the group aged 45 to 64(506,58.36%).(3)ADRs were mainly caused by intravenous infusion(664,76.23%).(4)Contrast agents caused the largest number of ADRs among the drugs used(171,19.63%),followed by anti-tumor drugs,hepatobiliary drugs and antibiotics.(5)The skin and subcutaneous tissues made up a large part of the systems/organs involved(407,38.61%).(6)Most of the patients recovered after treatment(847,97.69%).Conclusion The occurrence of ADRs is related to a wide range of factors.Clinical staff should pay attention to monitoring of ADRs to ensure safe and rational drug use.
作者
杜红丽
胡云英
范立青
王慧
鲍蕾蕾
DU Hong-li;HU Yun-ying;FAN Li-qing;WANG Hui;BAO Lei-lei(The Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China)
出处
《解放军药学学报》
CAS
2023年第3期199-202,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
药品不良反应
合理用药
adverse drug reaction
rational drug use
