摘要
目的探讨腹腔镜下局限性子宫腺肌症病灶切除术后联合促性腺激素释放激素-a(GnRH-a)、曼月乐治疗的效果分析。方法选取74例子宫腺肌症患者,按照随机抽签法分为对照组与试验组,每组37例。两组患者均接受腹腔镜下局限性子宫腺肌症病灶切除术,对照组患者在此基础上联合GnRH-a治疗,试验组在此基础上联合曼月乐治疗。比较两组患者的手术前后月经周期、经期和经量、疼痛情况及子宫体积变化。结果试验组患者术后24个月的月经周期稍短于对照组,但差异无差异意义(P>0.05)。试验组患者术后24个月的经期明显短于对照组,经量明显少于对照组(P<0.05)。试验组患者术后12、24个月视觉模拟评分法(VAS)评分均明显低于对照组,术后3个月、术后12个月子宫体积均明显大于对照组,术后24个月子宫体积明显小于对照组(P<0.05)。结论子宫腺肌症患者接受腹腔镜下局限性子宫腺肌症病灶切除术后,联合曼月乐的治疗效果优于联合GnRH-a治疗方案,有助于恢复患者术后子宫内环境,抑制子宫肌瘤复发,确保患者手术治疗的安全性。
Objective To explore the effect analysis of combined GnRH-aand Mirena therapeutic therapy after laparoscopic resection of localized adenomyosis lesions.Methods 74 patients with adenomyosis were selected and divided into the control group and the experimental group according to the random drawing method,37 cases in each group.Both groups of patients underwent laparoscopic resection of localized adenomyosis lesions.The control group was treated with GnRH-aon this basis,the experimental group was treated with Mirena on this basis.The menstrual cycle,menstrual period,menstrual volume,pain,and uterine volume changes before and after surgery between two groups were compared.Results The menstrual cycle of experimental group was slightly shorter than that of control group 24 months after surgery,but there was no difference(P>0.05).The period of 24 months after operation in experimental group was significantly shorter than that in control group,and the menstrual volume was significantly shorter than that in control group(P<0.05).The visual analogue scales(VAS)scores of experimental group were significantly lower than control group at 12 and 24 months after surgery;uterine volume at 3 and 12 months after surgery was significantly higher than control group;uterine volume at 24 months after surgery was significantly lower than control group(P<0.05).Conclusion After laparoscopic resection of localized adenomyosis lesions,the effect of drug treatment combined with Mirena is better than that of combined GnRH-atreatment regimen,which can help the postoperative uterine environment of patients,inhibit the recurrence of uterine fibroids,and ensure the safety of surgical treatment of patients.
作者
朱京津
李娟
郭楠楠
Zhu Jingjin;Li Juan;Guo Nannan(Department of Gynecology,Siyang Hospital,Suqian 223700,China)
出处
《实用妇科内分泌电子杂志》
2023年第4期23-25,共3页
Electronic Journal of Practical Gynecological Endocrinology
