摘要
应激诱导的免疫/炎症反应是抑郁症发生发展的关键病理机制,模式识别受体Toll样受体4(TLR4)/NOD样受体蛋白3(NLRP3)信号通路介导的免疫/炎症反应与抑郁症的形成和发展密切相关。中医药有关该通路抗抑郁的机制研究近年来成为关注点之一,中药复方如逍遥散、柴胡疏肝散、小建中汤等,中药药对如柴胡-白芍、桂枝-白芍、栀子-川芎等,中药单体如红花提取物、去氧五味子素、银杏酮酯、麝香酮、女贞子酚苷等可能通过抑制TLR4/NLRP3信号通路,下调TLR4、NLRP3、髓样分化因子88(MyD88)、核转录因子κB(NF-κB)、信号转接凋亡相关斑点样蛋白(ASC)等关键蛋白表达及白细胞介素1β(IL-1β)、白细胞介素18(IL-18)、肿瘤坏死因子α(TNF-α)等炎症因子水平,调控应激诱导的免疫/炎症反应,发挥抗抑郁作用。建议今后采用多种现代检测技术,从不同维度、不同层次,进一步探索中医药在TLR4/NLRP3信号通路中的抗抑郁机制,为中医药治疗抑郁症提供更多科学有力的证据。
The immune/inflammatory response induced by stress is a key pathological mechanism for the occurrence and development of depression.The immune/inflammatory response mediated by the Toll-like receptor 4(TLR4)/NOD like receptor protein 3(NLRP3)signaling pathway is closely related to the formation and development of depression.In recent years,researches on the antidepressant mechanism of the TLR4/NLRPS pathway in traditional Chinese medicine(TCM)has become a hot topic.TCM compound formulas such as Xiaoyao Powder(逍遥散),Chaihu Shugan Powder(柴胡疏肝散),and Xiaojianzhong Decoction(小建中汤),herbal pairs such as Chaihu(Radix Bupleuri)-Baishao(Radix Paeoniae Alba),Guizhi(Ramulus Cinnamomi)-Baishao(Radix Paeoniae Alba),and Zhizi(Fructus Gardeniae)-Chuanxiong(Rhizoma Chuanxiong),and monomers such as extract of Honghua(Flos Carthami),deoxyschizandrin,ginkgo ketone ester,muscone,and citrus glycosides,may be possible to inhibit the TLR4/NLRP3 signaling pathway and down-regulate the expression of key proteins such as TLR4,NLRP3,myeloid differentiation factor 88(MyD88),nuclear transcription factorκB(NF-κB),and signal transduction apoptosis-associated speck-like protein(ASC),as well as the levels of inflammatory factors such as interleukin 1β(IL-1β),interleukin 18(IL-18),and tumor necrosis factorα(TNF-α),thereby regulating stress-induced immune/inflammatory responses and exert antidepressant effects.It is suggested that various modern detection techniques be used in the future to further explore the antidepressant mechanism of TLR4/NLRP3 signaling pathway from different dimensions and levels,so as to provide more scientific and powerful evidence for the treatment of depression with TCM.
作者
张勇
刘美君
李锐锋
蔡君洁
何媛
常文
邓鑫敏
梁静涛
ZHANG Yong;LIU Meijun;LI Ruifeng;CAI Junjie;HE Yuan;CHANG Wen;DENG Xinmin;LIANG Jingtao(Chengdu University of Traditional Chinese Medicine,Chengdu,610075;Hospital of Chengdu University of Traditional Chinese Medicine)
出处
《中医杂志》
CSCD
北大核心
2023年第11期1179-1184,共6页
Journal of Traditional Chinese Medicine
基金
四川省科学技术厅重点研发项目(2021YFS0260)。
