摘要
椎间盘退变(IDD)是脊柱退行性疾病的重要病理基础,可引发椎间盘突出、椎管狭窄、脊柱退变性畸形等并发症,严重影响人类健康和生活质量。在人椎间盘发育早期,存在形态较大、富含囊泡的脊索细胞和形态较小、无囊泡的髓核细胞。然而,随着人年龄的增长脊索细胞逐渐消失,与此同时早期IDD开始出现。研究表明,脊索细胞可通过保护髓核细胞维持椎间盘正常生理功能。同时,脊索细胞还可抑制血管神经浸润维持椎间盘内环境稳态。此外,脊索细胞还可诱导干细胞向髓核细胞表型分化。然而,以上相关机制研究仍处于早期,脊索细胞在椎间盘中的重要地位仍未被完全阐明。因此,深入研究脊索细胞在椎间盘正常功能调控的机制和相关通路、探索其对IDD的生物治疗可能具有重要意义。
Intervertebral disc degeneration(IDD)is an important pathological basis of spinal degenerative diseases,which can cause complications such as intervertebral disc herniation,spinal canal stenosis and degenerative spinal deformity,seriously affecting human health and quality of life.In the early development of human intervertebral disc,there are large vesicle-rich notochordal cells and small vesicle-free nucleus pulposus cells.However,notochordal cells gradually disappear with aging,and at the same time early IDD begins to appear.Studies have shown that notochordal cells can maintain the normal physiological function of intervertebral disc by protecting nucleus pulposus cells.Meanwhile,notochordal cells can also inhibit vascular nerve infiltration and maintain the homeostasis of the intervertebral disc.In addition,notochordal cells can induce phenotypic differentiation of stem cells into nucleus pulposus cells.However,the above related mechanisms are still in the early stage,and the important role of notochordal cells in the intervertebral disc has not been fully elucidated.Therefore,it might be of great significance to further study the mechanism and related pathways of notochordal cells in regulating the normal function of intervertebral disc and explore the biological treatment of IDD.
作者
孙振
段伟
常乐
赵昕
许奔驰
罗卓荆
叶正旭
SUN Zhen;DUAN Wei;CHANG Le;ZHAO Xin;XU Benchi;LUO Zhuojing;YE Zhengxu(Department of Orthopedics,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
出处
《空军军医大学学报》
CAS
2023年第6期486-489,共4页
Journal of Air Force Medical University
基金
国家自然科学基金青年科学基金(82002348)
陕西省自然科学基础研究计划项目(2020JM-319)。
关键词
椎间盘
脊索细胞
生物治疗
intervertebral disc
notochordal cell
biological treatment
