摘要
目的分析血清铁蛋白(SF)、血管内皮细胞生长因子(VEGF)联合血清癌胚抗原(CEA)检测在乳腺癌诊断、复发转移预测中的价值。方法选取2020年2月至2022年1月东营市人民医院收治的104例乳腺疾病患者,病理学检查结果显示54例为乳腺癌患者,将其纳入观察组,50例良性乳腺疾病患者,纳入对照组。对比两组血清SF、VEGF及CEA水平,分析SF、VEGF及CEA单独检测与联合检测在乳腺癌诊断中的敏感性及特异性。随访12个月,根据肿瘤复发转移情况将观察组分为未复发转移组与复发转移组,比较两组血清SF、VEGF及CEA水平,并分析三者联合检测对乳腺癌复发转移的预测价值。结果观察组患者血清SF、VEGF及CEA水平均高于对照组,差异具有统计学意义(P<0.05)。在乳腺癌的诊断中,SF、VEGF及CEA联合检测的敏感性和特异性均高于单项检测(P<0.05)。在54例乳腺癌患者中,发生复发转移的患者有11例,未复发转移的患者有43例。复发转移组患者血清SF、VEGF及CEA水平均高于未复发转移组,差异具有统计学意义(P<0.05)。依据ROC曲线可知,SF、VEGF及CEA联合检测乳腺癌复发转移的敏感度和特异度分别为0.819和0.802,AUC=0.843(95%CI:0.761~0.926),明显高于单项检测(P<0.05)。结论乳腺癌患者血清SF、VEGF及CEA表达水平均升高,三者联合检测在乳腺癌的诊断及术后复发转移的预测中具有重要的指导意义。
Objective To analyze the value of serum ferritin(SF),vascular endothelial growth factor(VEGF)combined with serum carcinoembryonic antigen(CEA)detection in the diagnosis and predic⁃tion of recurrence and metastasis of breast cancer.Methods A total of 104 patients with breast diseases admit⁃ted to Dongying People's Hospital from February 2020 to January 2022 were selected.Pathological examina⁃tion results showed that 54 patients with breast cancer were included in the observation group,and 50 patients with benign breast diseases were included in the control group.The serum SF,VEGF,and CEA levels be⁃tween the two groups were compared,and the sensitivity and specificity of SF,VEGF,and CEA alone and combined detection in the diagnosis of breast cancer were analyzed.After 12 months of follow⁃up,the observa⁃tion group was divided into the non⁃recurrence metastasis group and the recurrence metastasis group according to tumor recurrence and metastasis.Serum SF,VEGF,and CEA levels between the two groups were com⁃pared,and the predictive value of the combined detection of the three on breast cancer recurrence and metasta⁃sis was analyzed.Results The levels of serum SF,VEGF and CEA in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).In the diagnosis of breast cancer,the sensitivity and specificity of combined detection of SF,VEGF and CEA were higher than those of single detection,and the difference was statistically significant(P<0.05).Among the 54 breast cancer patients,there were 11 patients with recurrence and metastasis,and 43 patients without recurrence and metastasis.The levels of serum SF,VEGF and CEA in the recurrence and metastasis group were higher than those in the non⁃re⁃lapse and metastasis group,and the difference was statistically significant(P<0.05).According to the ROC curve,the sensitivity and specificity of SF,VEGF and CEA combined detection of breast cancer recurrence and metastasis were 0.819 and 0.802,respect
作者
杨建美
王芳
王秀云
杨三华
聂尧尧
YANG Jianmei;WANG Fang;WANG Xiuyun;YANG Sanhua;NIE Yaoyao(Department of Oncology,Dongying People's Hospital,Dongying,Shandong,China,257091;Department of Pharmacy,Lijin County Hospital of Traditional Chinese Medicine,Dongying,Shandong,China,2257447)
出处
《分子诊断与治疗杂志》
2023年第5期801-804,共4页
Journal of Molecular Diagnostics and Therapy
基金
山东省医药卫生科技发展计划项目(2020WS15583)。
