摘要
目的探究内镜下套扎治疗对肝硬化伴食管胃底静脉曲张患者胃泌素⁃17(GAS⁃17)、胃动素(MTL)及生长抑素(SS)的影响。方法选择2019年3月至2022年4月间北京市石景山医院收治的84例肝硬化伴食管胃底静脉曲张患者,根据治疗方法分为对照组(改良三明治法治疗,n=41)、观察组(对照组基础上进行内镜下套扎,n=43)。对比两组胃肠激素水平(包括GAS⁃17、MTL、SS)、疗效、临床指标(包括输血量、止血时间、住院时间及近期再出血率)及并发症情况。结果治疗后观察组GAS⁃17、MTL水平低于对照组,SS水平高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率达88.37%,明显高于对照组(70.73%),差异有统计学意义(P<0.05);观察组输血量、近期再出血率均低于对照组,其止血时间、住院时间均短于对照组,差异有统计学意义(P<0.05);观察组总并发率仅9.30%,明显低于对照组的26.83%,差异有统计学意义(P<0.05)。结论内镜下套扎治疗能改善肝硬化伴食管胃底静脉曲张患者胃肠状态,快速阻断血流,安全性较高,值得临床广泛应用。
Objective To investigate the effects of endoscopic band ligation on gastrin⁃17(GAS⁃17),motilin(MTL)and somatostatin(SS)in patients with liver cirrhosis and esophagogastric varices.Methods 84 patients with liver cirrhosis and esophagogastric varices admitted to Beijing Shijingshan Hospital from March 2019 and April 2022 were selected,and according to the treatment methods,they were divided into the control group(modified sandwich treatment,n=41)and the observation group(the control group underwent endoscopic band ligation on the basis of the control group,n=43).The levels of gastrointestinal hormones(GAS⁃17,MTL,SS),curative effects,clinical indicators(blood transfusion volume,hemostasis time,hospitalization time and recent re⁃bleeding rate)and complications between the two groups were compared.Results After treatment,the levels of GAS⁃17 and MTL in the observation group were lower than those in the control group,while the level of SS was higher than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate in the observation group was 88.37%,which was significantly higher than that in the control group(70.73%),and the difference was statistically significant(P<0.05).The bleeding transfusion volume and recent re⁃bleeding rate in the observation group were lower than those in the control group,and the hemostasis time and hospital stay in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).The total incidence in the observation group was 9.30%,which was significantly lower than that in the control group(26.83%),and the difference was statistically significant(P<0.05).Conclusion Endoscopic band ligation can improve the gastrointestinal status of patients with liver cirrhosis and esophagogastric varices,and quickly block the blood flow,and has high safety,which is worthy of extensive clinical application.
作者
陆玓
高杨
张莉
LU Di;GAO Yang;ZHANG Li(Department of Gastroenterology,Shijingshan Hospital,Beijing,China,100040)
出处
《分子诊断与治疗杂志》
2023年第5期755-758,763,共5页
Journal of Molecular Diagnostics and Therapy
基金
北京市卫生科技发展专项基金(2019⁃2⁃254)。
