摘要
目的探讨变应性鼻炎(allergic rhinitis,AR)患者鼻呼出气一氧化氮(nasal fractional exhaled nitric oxide,nFeNO)、骨桥蛋白(osteopontin,OPN)、特异性IgE(specific immunoglobulin E,sIgE)表达情况及对合并哮喘的辅助诊断价值。方法选取AR患者228例为观察组,其中单纯AR 187例,AR合并哮喘41例;同期选取45例健康体检者为对照组。比较两组nFeNO、OPN、sIgE水平,分析AR患者nFeNO、OPN、sIgE水平与鼻部症状总评分(Total Nasal Symptom Score,TNSS)评分相关性,Logistic回归分析AR合并哮喘的独立影响因素,受试者工作特征(receiver operating characteristic,ROC)曲线分析nFeNO、OPN、sIgE对AR合并哮喘的诊断价值。结果观察组nFeNO、OPN、sIgE水平高于对照组(P<0.05);AR患者nFeNO、OPN、sIgE水平与TNSS评分呈正相关(P<0.05);Logistic回归分析显示,nFeNO、OPN、sIgE水平升高均为AR合并哮喘的独立危险因素(P<0.05);ROC曲线显示,nFeNO、OPN、sIgE联合诊断AR合并哮喘的AUC值为0.829,高于单独诊断。结论AR患者nFeNO、OPN、sIgE水平与TNSS评分呈正相关,且AR合并哮喘具有良好预测和辅助诊断作用。
Objective To investigate the expressions of nasal fractional exhaled nitric oxide(nFeNO),osteopontin(OPN)and specific immunoglobulin E(sIgE)in patients with allergic rhinitis(AR)and their value in auxiliary diagnosis of asthma.Methods A total of 228 AR patients in our hospital were selected as the observation group,including 187 patients with pure AR and 41 patients with AR combined with asthma;45 healthy people undergoing physical examination during the same period were selected as the control group.The levels of nFeNO,OPN,and sIgE between two groups were compared,and the correlation between the levels of nFeNO,OPN,and sIgE in AR patients and total nasal symptom score(TNSS)score was analyzed.Logistic regression analysis was used to analyze the independent influencing factors of AR with asthma,and receiver operating characteristic(ROC)curve analysis was used to analyze the diagnostic value of nFeNO,OPN and sIgE for AR complicated with asthma.Results The levels of nFeNO,OPN and sIgE in the observation group were higher than those in the control group(P<0.05).The levels of nFeNO,OPN and sIgE in AR patients were positively correlated with the TNSS score(P<0.05).Logistic regression analysis showed that the increased levels of nFeNO,OPN and sIgE were independent risk factors for AR complicated with asthma(P<0.05).The ROC curve showed that the AUC value of nFeNO,OPN and sIgE in combination to diagnose AR complicated with asthma was 0.829,which was higher than that of single indicator in diagnosis.Conclusion The levels of nFeNO,OPN and sIgE in AR patients are positively correlated with the TNSS score,and are of great value in prediction and auxiliary diagnosis of AR complicated with asthma.
作者
李君
叶方
韩富光
李波
LI Jun;YE Fang;HAN Fu-guang;LI Bo(Department of Otolaryngology,Danzhou People′s Hospital,Hainan Province,Danzhou 571799,China;Department of Otolaryngology Head and Neck Surgery,Hainan West Central Hospital,Danzhou 571799,China)
出处
《河北医科大学学报》
CAS
2023年第6期697-701,共5页
Journal of Hebei Medical University
基金
海南省卫生计生行业科研项目(2001320114A2005)。
