摘要
恒定自然杀伤T细胞(invariant natural killer T cells,iNKT)又称为I型NKT细胞,是一类能够识别CD1d分子提呈的脂类抗原的天然T细胞亚群。iNKT细胞包括不同亚群,各亚群具有独特的表型和功能特点,表面标志物分子或转录因子常作为iNKT细胞分群依据。iNKT细胞亚群可以抗感染、抗肿瘤、抗炎和维持组织内环境稳态。然而,活化的iNKT细胞亚群也参与一些疾病的致病机制。文章主要以iNKT细胞表面标志物分子和转录因子为依据阐述iNKT细胞亚群表型特点及其免疫功能。
Invariant natural killer T cells(iNKT),also called as type I NKT cells,are a natural subset of T cells that can recognize lipid antigens presented by CD1d molecules.By expressing different surface markers or transcription factors,iNKT cells can be separated into different subgroups.iNKT subsets play important roles in protection from infection,regulating tumor and inflammation immunity as well as maintaining the tissue homeostasis.While activated iNKT cell subsets are also involved in the pathogenesis of some diseases.This review mainly discussed the phenotypical and functional properties of iNKT subsets divided based on the surface markers or the transcription factors.
作者
钟洁莹
倪海阳
聂汉祥
Zhong Jieying;Ni Haiyang;Nie Hanxiang(Department of Respiratory and Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《国际免疫学杂志》
CAS
2023年第3期294-299,共6页
International Journal of Immunology
基金
国家自然科学基金(82170021)。
关键词
恒定自然杀伤T细胞
表面标志物
转录因子
免疫功能
Invariant natural killer T cells
Surface marker
Transcription factor
Immune functions
