摘要
非酒精性脂肪性肝病(NAFLD)在全球的发病率日益上升,已成为第一大慢性肝病和健康体检中肝生化指标异常的首要原因。NFALD发病机制复杂,与腺苷酸活化蛋白激酶(AMPK)参与的脂质代谢紊乱、过度氧化、自噬、炎症级联反应等有着密不可分的关系。近年来中药干预NAFLD已成为研究热点,从AMPK方面论述中药复方、单体在治疗NAFLD中的作用,为NAFLD防治提供新的理论依据。
The incidence of non-alcoholic fatty liver disease(NAFLD)is on the rise worldwide,It has become the first major chronic liver disease and the primary cause of abnormal liver biochemical indexes in health examination.It is closely related to adenosine-activated protein kinase(AMPK)involved in lipid metabolism disorders,excessive oxidation,autophagy and inflammatory cascade reactions.In recent years,the intervention of Traditional Chinese medicine in NAFLD has become a research hot spot.The role of TCM compound and monomer in the treatment of NAFLD is discussed from the perspective of AMPK,providing a new theoretical basis for the prevention and treatment of NAFLD.
作者
周琳
周晓玲
梁甜
Zhou Lin;Zhou Xiaoling;Liang Tian(Graduate School,Guangxi University of Chinese Medicine,Nanning 530001,China;Gastroenterology,Liuzhou Hospital of Traditional Chinese Medicine,Liuzhou 545ool,China)
出处
《亚太传统医药》
2023年第6期217-222,共6页
Asia-Pacific Traditional Medicine
基金
国家自然科学基金(81760855)
广西研究生教育创新计划资助项目(YCSY2020106)
柳州市科技重大专项(2018AF10503)。
关键词
NAFLD
AMPK
中药干预
研究进展
NAFLD
AMPK
Traditional Chinese Medicine Intervention
Research Progress
