摘要
偏头痛在中国是一种常见的搏动性、原发性的头痛病,多一侧起病,重者可致残,对患者的生活质量产生重大影响,是目前治疗的一大难点。中医治疗偏头痛既可以改善疾病的症状,还可以祛除疾病的根源,具有多目标、多途径的特点。通过对治疗偏头痛的古今医案数据进行分析,发现中医治疗主要采取祛瘀、平肝阳、补虚三种治疗策略。其中化瘀方中大多含有川芎,发现川芎可以活血化瘀,改善血液流变学性质,镇静,镇痛,清除氧自由基,同时也发现含有川芎的药对居于偏头痛治疗使用药对之首。川芎是临床上治疗头痛、血管性头痛、偏头痛用药频率最高的单味中药之一。该文对川芎治疗偏头痛的药理作用机制进行综述,为川芎临床治疗和预防偏头痛提供理论科学依据。并对川芎的有效成分现代研究进行归纳梳理。结果发现川芎治疗偏头痛的药理机制包括抑制氧自由基活性,减轻炎症反应;抗神经元凋亡,保护脑神经;调节神经递质,降低痛阈值;抗血小板聚集;调肠道菌群等。
Migraine is a common pulsatile,primary headache disease in China,multiple side onset,serious cases can be disabled,have a significant impact on the quality of life of patients,is a major difficulty in the current treatment.The treatment of migraine can not only improve the symptoms of the disease,but also dispel the root cause of the disease,which has the characteristics of multi-goal and multi-channel.Through the analysis of the ancient and modern medical case data for migraine treatment,it is found that three main treatment strategies are removing blood stasis,smoothing liver Yang and tonifying deficiency.Most of the prescriptions contain Chuanxiong(Chuanxiong Rhizoma).It is found that Chuanxiong(Chuanxiong Rhizoma)can promote blood circulation and remove blood stasis,and improve the properties of blood rheology.Meanwhile,it is also found that the drugs containing Chuanxiong(Chuanxiong Rhizoma)are the first drugs in the treatment of migraine.Chuanxiong(Chuanxiong Rhizoma)is one of the most common traditional Chinese medicine to treat headache,vascular headache and migraine.This paper summarizes the pharmacological mechanism of Chuanxiong(Chuanxiong Rhizoma)in migraine treatment to provide a theoretical and scientific basis for the clinical treatment of migraine.The modern study of the active components of Chuanxiong(Chuanxiong Rhizoma)is summarized and sorted out.The results showed that the pharmacological mechanism of migraine treatment included inhibiting oxygen free radical activity,reducing inflammation,anti-neuronal apoptosis,brain nerve protection,neurotransmitter regulation,pain threshold reduction,anti-platelet aggregation,and modulation of intestinal flora.
作者
柴金秀
张禹
吕永旭
徐冰
CHAI Jinxiu;ZHANG Yu;LYU Yongxu;XU Bing(Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China;The First Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,Shaanxi,China)
出处
《辽宁中医药大学学报》
CAS
2023年第5期102-106,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金项目(81973843)
陕西省教育厅重点实验室项目(20JS036)
陕西省教育厅重点实验室项目(21JS013)
陕西省科学技术研究发展计划项目(2013k12-01-19)
陕西中医药大学附属医院中医临床研究基地项目(2020LCJD002)
陕西中医药大学校级课题立项项目(2013CX13)。
关键词
偏头痛
川芎
川芎嗪
阿魏酸钠
藁本内酯
药理机制
migraine
Chuanxiong(Chuanxiong Rhizoma)
ligustrazine
sodium ferulate
chaff lactone
pharmacological mechanism
