摘要
氧化应激在多种心血管疾病的发病机制中起着重要作用。核因子E2相关因子2(Nrf2)是机体调节氧化应激的关键转录因子,也是氧化应激相关疾病的新兴治疗靶点。虾青素是类胡萝卜素的一种,具有极强的抗炎、抗氧化作用,被认为在心血管疾病中发挥良好的保护作用。多项研究表明虾青素能通过激活Nrf2通路改善血脂、血糖异常,抑制血管钙化,延缓动脉粥样硬化的发展,减轻心肌损伤并改善心力衰竭,在防治心血管疾病方面具有广阔前景。
Oxidative stress plays an important role in the pathogenesis of various cardiovascular diseases.Nuclear factor-erythroid 2-related factor 2(Nrf2)is a key regulator of oxidative stress,acting as an emerging and promising target for these diseases.Astaxanthin,a kind of carotenoid,possessing strong anti-inflammatory and antioxidant capacity,is considered to be beneficial in the protection of cardiovascular diseases.Studies have shown that astaxanthin can improve blood lipids and blood glucose,inhibit vascular calcification,delay the development of atherosclerosis,alleviate myocardial injury and improve heart failure by activating Nrf2 pathway.
作者
陆婵君
郭艺
胡可
李浴萱
王维慈
LU Chan-jun;GUO Yi;HU Ke;LI Yu-xuan;WANG Wei-ci(Department of Vascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan HUBEI 430030,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2023年第5期284-288,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
国家自然科学基金面上项目(81873529)
国家自然科学基金青年基金(81500376)。
