摘要
目的分析根治性膀胱切除术(RCP)患者伴偶发前列腺癌的危险因素及其临床意义。方法回顾性分析2012年1月-2022年1月在新疆医科大学第一附属医院接受RCP治疗患者共260例的临床及病理资料,其中术后病理检出偶发前列腺癌共39例(有IPCa组),未检出偶发前列腺癌共221例(无IPCa组)。结果偶发前列腺癌的检出率为15%。单因素logistic回归分析结果显示年龄(P<0.001)、吸烟(P<0.05)、T分期(P<0.05)、肿瘤数目(P<0.05)、是否及膀胱三角(P<0.05)、前列腺体积(P<0.05)、术前总PSA(P<0.001)为膀胱癌发生前列腺癌的影响因素;多因素logistic回归分析表明年龄(OR=1.061,95%CI:1.021~1.107,P=0.004)、吸烟(OR=2.852,95%CI:1.296~6.677,P=0.012)、是否及膀胱三角(OR=2.967,95%CI:2.365~3.657,P=0.019)、术前总PSA(OR=1.109,95%CI:1.011~1.223,P=0.030)是偶发前列腺癌的独立危险因素。结论高龄、吸烟、膀胱肿瘤位于三角区及术前前列腺特异性抗原(PSA)异常是膀胱癌患者伴发偶发性前列腺癌的危险因素。
Objective To investigate the risk factors and clinical significance of incidental prostate cancer(IPCa)in patients undergoing radical cystoprostatectomy(PCR).Methods The clinicopathological data of 260 patients undergoing RCP in our hospital during Jan.2010 and Jan.2022 were retrospectively analyzed,including 39 cases of IPCa detected with postoperative pathology,and 221 non-IPCa cases.Results The detection rate of IPCa was 15%.Univariate logistic regression analysis showed age(P<0.001),smoking(P<0.05),T stage(P<0.05),number of tumors(P<0.05),involvement of trigone(P<0.05),prostate volume(P<0.05),and preoperative total prostate-specific antigen(tPSA)(P<0.05)were influencing factors of prostate cancer.Multivariate logistic regression analysis showed that age(OR=1.061,95%CI:1.021-1.107,P=0.004),smoking(OR=2.852,95%CI:1.296-6.677,P=0.012),involvement of trigone(OR=2.967,95%CI:2.365-3.657,P=0.019)and preoperative tPSA(OR=1.109,95%CI:1.011-1.223,P=0.030)were independent risk factors of IPCa.Conclusion Advanced age,smoking,bladder tumor in trigone and preoperative PSA abnormality are risk factors for incidental prostate cancer in bladder cancer patients.
作者
凯买尔丁·阿布都艾尼
娜依拉·木拉提
李前进
艾克拜尔江·卡米力
木拉提·热夏提
KAIERMAIDING Abuduaini;NAYILA Mulati;LI Qianjin;AIKEBAIERJIANG Kamili;MULATI Rexiati(Department of Urology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054;First Cliniccil Medical College of Xinjiang Medical University,Urumqi 830054,China)
出处
《现代泌尿外科杂志》
CAS
2023年第6期469-473,共5页
Journal of Modern Urology
基金
国家自然科学基金地区科学基金项目(No.82260109039)。
