摘要
目的探讨左乙拉西坦(levetiracetam,LEV)在预防小儿复杂性热性惊厥复发及发展为癫痫中的效果及安全性。方法方便选取2019年1月—2021年1月汕头市妇幼保健院收治的62例复杂性热性惊厥患儿作为研究对象,根据治疗方案不同分为A组(32例)和B组(30例)。A组采用左乙拉西坦治疗,B组采用地西泮治疗,比较两组的治疗效果,复发率及癫痫转化率,脑神经因子水平,免疫功能水平和不良反应发生率。结果A组治疗有效率为100.00%,高于B组的80.00%,差异有统计学意义(χ^(2)=4.982,P=0.026)。A组的复发率低于B组,差异有统计学意义(χ^(2)=5.985,P=0.014)。A组的癫痫转化率低于B组,差异无统计学意义(χ^(2)=2.619,P=0.106)。A组治疗后的脑神经相关因子(BDNF、S-100β、NSE)水平及免疫功能(IgA、IgG、IgM)水平均低于B组,差异有统计学意义(P<0.05)。A组不良反应发生率低于B组,差异无统计学意义(χ^(2)=0.799,P=0.371)。结论左乙拉西坦在预防复杂性热性惊厥复发和发展为癫痫中的效果良好,且该药物引发的不良反应程度比较轻。
Objective To investigate the efficacy and safety of Levetiracetam(LEV)in preventing recurrent febrile convulsions and development of epilepsy in children.Methods 62 children with complex febrile seizures admitted to Shantou Maternal and Child Health Hospital from January 2019 to January 2021 were conveniently selected as the research subjects.They were divided into group A(32 cases)and group B(30 cases)according to different treatment plans.Group A was treated with levetiracetam,while group B was treated with diazepam.The therapeutic effects,recurrence rate,epilepsy conversion rate,neurologic factor level,immune function level and incidence of adverse reactions of the two groups were compared.Results The effective rate of treatment in group A was 100.00%,higher than that in group B(80.00%),and the difference was statistically significant(χ^(2)=4.982,P=0.026).The recurrence rate of group A was lower than that of group B,and the difference was statistically significant(χ^(2)=5.985,P=0.014).The conversion rate of epilepsy in group A was lower than that in group B,and the difference was not statistically significant(χ^(2)=2.619,P=0.106).After treatment,the levels of brain nerve related factors(BDNF,S-100β,NSE)and immune function(IgA,IgG,IgM)in group A were lower than those in group B,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in group A was lower than that in group B,and the difference was not statistically significant(χ^(2)=0.799,P=0.371).Conclusion Levetiracetam is effective in preventing the recurrence of complex febrile convulsions and the development of epilepsy,and the degree of adverse reactions caused by the drug is relatively mild.
作者
林健辉
姜尚林
LIN Jianhui;JIANG Shanglin(Department of Pediatrics,Shantou Maternal and Child Health Care Hospital,Shantou,Guangdong Province,515041 China)
出处
《中外医疗》
2023年第10期146-149,共4页
China & Foreign Medical Treatment
关键词
复杂性热性惊厥
左乙拉西坦
地西泮
癫痫
不良反应
Complex febrile convulsion
Levetiracetam
Diazepam
Epilepsy
Adverse reaction
