摘要
目的 探讨肠道菌群移植(fecal microbiota transplantation, FMT)联合益生菌和益生元治疗慢传输型便秘(slow transit constitution, STC)的临床疗效。方法 回顾性收集2021年5月至2022年10月在湖北医药学院附属国药东风总医院接受FMT联合益生菌和益生元治疗的STC病人30例,年龄为(67.13±7.16)岁,治疗前便秘病史为(13.97±4.43)年,1周排便次数为(2.15±0.67)次。记录移植前后临床治愈率、临床缓解率、结肠传输试验结果、每周自主排便次数、Wexner便秘评分、Bristol粪便性状评分,并随访8周。结果 30例病人经FMT联合益生菌和益生元治疗后,病人第8周临床治愈率维持在50.0%(15/30),临床缓解率为60.0%(18/30)。FMT治疗第8周时与FMT前比较,自主排便次数明显增加[(3.03±1.17)次/周比(2.15±0.67)次/周],结肠传输试验评分明显下降[(5.53±2.41)分比(10.13±1.41)分],Wexner便秘评分明显下降[(9.83±4.53)分比(15.63±3.69)分],Bristol评分改善[(2.80±0.99)分比(1.26±0.52)分],差异均有统计学意义(均P<0.05)。在治疗后及随访期间均未发生严重不良反应。结论 FMT联合益生菌和益生元可安全有效地治疗STC,改善病人便秘症状。
Objective To explore the clinical efficacy of fecal microbiota transplantation(FMT)plus probiotics and prebiotics for slow transit constipation(STC).Methods From May 2021 to October 2022,30 STC patients underwent FMT.There were 11 males and 19 females with an age range of(67.13±7.16)years.History of constipation pre-treatment was(13.97±4.43)years and weekly frequency of defecation(2.15±0.67).Clinical curative rate,clinical remission rate,colonic transit test results,weekly frequency of autonomous defecation,Wexner constipation score and Bristol stool character score pre/post-transplantation were recorded during a follow-up period of 8 weeks.Results After FMT plus probiotics and prebiotics,clinical curative rate at Week 8 was maintained at 50.0%(15/30),clinical remission rate reached 60.0%(18/30),weekly frequency of spontaneous defecation increased markedly[(3.03±1.17)vs.(2.15±0.67)times/week],score of colon transit test declined markedly[(5.53±2.41)vs.(10.13±1.41)points],score of Wexner constipation decreased markedly[(9.83±4.53)vs.(15.63±3.69)points]and Bristol score improved[(2.80±0.99)vs.(1.26±0.52)].The differences were statistically significant(P<0.05).No serious adverse reactions occurred after treatment and during follow-ups.Conclusion FMT plus probiotics and prebiotics can safely and effectively treat STC and improve constipation symptoms of patients.
作者
王丙开
王志
周培华
刘小倩
刘晓静
胡学义
王啸然
袁方均
Wang Bingkai;Wang Zhi;Zhou Peihua;Liu Xiaoqian;Liu Xiaojing;Hu Xueyi;Wang Xiaoran;Yuan Fangjun(Department of General Surgery,Dongfeng General Hospital of Sinopharm Affiliated to Hubei Medical College,Hubei Shiyan 442000,China)
出处
《腹部外科》
2023年第3期232-235,239,共5页
Journal of Abdominal Surgery
基金
湖北省教育厅科学技术研究项目(B2020108)。
关键词
肠道菌群移植
慢传输型便秘
益生菌
益生元
Fecal microbiota transplantation
Slow transit constipation
Probiotics
Prebiotics
