摘要
目的分析缺血性脑卒中后癫痫的影响因素。方法选取华中科技大学同济医学院附属梨园医院2019年3月至2021年3月收治的146例缺血性脑卒中病人和149例健康体检者,分别记为疾病组(n=146)和健康组(n=149)。疾病组治疗前抽取外周血、健康组采用体检剩余外周血测定血清微RNA-181a(miR-181a)表达并比较;疾病组随访1年比较癫痫组与无癫痫组血清miR-181a表达;以logistic多元回归分析探讨缺血性脑卒中后癫痫的影响因素。结果疾病组血清miR-181a表达高于健康组(P<0.001);疾病组癫痫发生率为26.71%,其中早发型癫痫、迟发型癫痫、单次发作、反复发作、癫痫大发作、小发作、局灶性发作、精神运动性发作构成比分别为38.46%、61.54%、43.59%、56.41%、64.10%、10.26%、20.51%、5.13%;癫痫组血清miR-181a表达高于无癫痫组[(1.84±0.40)比(1.58±0.35)](P<0.001);癫痫组入院NIHSS评分高于无癫痫组[(15.22±2.38)分比(9.88±2.07)分](P<0.001),出血性转化占比高于无癫痫组(25.64%比11.21%)(P=0.031),且入院美国国立卫生研究院脑卒中量表(NIHSS)评分、出血性转化与血清miR-181a表达均为缺血性卒中后癫痫的危险因素。结论缺血性脑卒中病人血清miR-181a表达升高,癫痫的发生风险高,且入院NIHSS评分、出血性转化、血清miR-181a表达均是其危险因素。
Objective To analyze the influencing factors for epilepsy after ischemic stroke.Methods A total of 149 patients with ischemic stroke and 146 healthy persons treated in Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from March 2019 to March 2021 were selected and recorded as disease group(n=146)and health group(n=149),respectively.The expression of serum microrna-181a(miR-181a)was detected and compared between the disease group and the healthy group.The disease group was followed up for 1 year to compare the expressions of serum miR-181a between epilepsy group and no-epilepsy group.Logistic multiple regression analysis was used to explore the influencing factors of secondary epilepsy in the disease group.Results The expression of serum miR-181a in the disease group was higher than that in the healthy group(P<0.001),and the incidence of epilepsy in the disease group was 26.71%.Among them,early-onset epilepsy,late-onset epilepsy,single seizure,recurrent seizures,major seizures,minor seizures,focal seizures and psychomotor seizures accounted for 38.46%,61.54%,43.59%,56.41%,64.10%,10.26%,20.51% and 5.13%,respectively.The expression of serum miR-181a in epilepsy group was higher than that in no-epilepsy group[(1.84±0.40)vs.(1.58±0.35)](P<0.001).The NIHSS score in the epilepsy group was significantly higher than that in the no-epilepsy group[(15.22±2.38)vs.(9.88±2.07)](P<0.001),and the hemorrhagic transformation in the epilepsy group were significantly higher than those in the no-epilepsy group(25.64%vs.11.21%)(P=0.031),and the NIHSS score,hemorrhagic transformation and serum miR-181a expression were risk factors for epilepsy.Conclusion The expression of serum miR-181a in patients with ischemic stroke is increased,and the risk of epilepsy is high,and NIHSS score and hemorrhagic transformation and the expression of serum miR-181a are risk factors.
作者
李丹
徐沙丽
陈乔
LI Dan;XU Shali;CHEN Qiao(Department of Neurology,Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430077,China;Cardiovascular Clinical Medical Center,Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430077,China)
出处
《安徽医药》
CAS
2023年第7期1400-1403,共4页
Anhui Medical and Pharmaceutical Journal
基金
武汉市卫生和计划生育委员会资助项目(WZ18Q07)。
