摘要
目的比较早卵泡期长效长方案与拮抗剂方案在助孕治疗的卵巢正常反应病人中的应用效果。方法回顾性分析2019年1月至2021年12月于济南市中心医院生殖医学中心行体外受精-胚胎移植(IVF-ET)/卵胞浆内单精子注射(ICSI)助孕治疗的卵巢正常反应病人的临床资料。该研究共计587个周期,包括365个早卵泡期长效长周期(长效长方案组)和222个拮抗剂周期(拮抗剂方案组)。比较两组病人的一般资料、促排卵及胚胎情况、新鲜周期胚胎移植情况、临床结局以及全胚冷冻后首次冻融胚胎移植病人的一般资料、内膜准备情况、胚胎移植情况及临床结局。结果早卵泡期长效长方案组的促性腺激素(Gn)总量、Gn天数、扳机日雌二醇浓度、内膜厚度、获卵数均大于拮抗剂组(P<0.05)。新鲜周期中,早卵泡期长效长方案组临床妊娠率和着床率均高于拮抗剂组(55.52%比44.12%,41.13%比30.23%,P<0.05)。拮抗剂组扳机日黄体生成素(LH)浓度和新鲜周期取消移植率高于长效长方案组(P<0.05)。结论卵巢正常反应病人新鲜周期胚胎移植应用早卵泡期长效长方案临床妊娠率高,取消移植率低,更能使病人获益;但对于全胚冷冻后首次冻胚移植,两种方案的妊娠结局并无差异。
Objective To compare the efficacy of the early follicular phase prolonged protocol and antagonist protocol in patients with normal ovarian response during pregnancy assisted treatment.Methods The clinical data of patients with normal ovarian response who underwent in vitro fertilization-embryo transfer(IVF-ET)/intracytoplasmic sperm injection(ICSI)in reproductive Medicine Center of Jinan Central Hospital from January 2019 to December 2021 was retrospectively analyzed.A total of 587 cycles were included,including 365 early follicular phase prolonged cycles(the follicular phase prolonged protocol group)and 222 antagonist cycles(antagonist protocol group).The general information,ovulation induction and embryo status,fresh cycle embryo transfer status,clinical outcomes between the two groups and the general data,endometrial preparation,embryo transfer and clinical outcomes of patients with the first frozen-thawing embryo transfer after freeze-all were compared.Results The total amount of Gn,Gn days,HCG day estradiol(E2)concentration,endometrial thickness and the number of eggs obtained in the follicular phase prolonged protocol group were higher than those in the antagonist group(P<0.05).In fresh cycles,the clinical pregnancy rate and implantation rate in the follicular phase prolonged protocol group were higher than those in the antagonist group(55.52%vs.44.12%,41.13%vs.30.23%,P<0.05).The luteinizing hormone(LH)concentration and transplantation cancellation rate in fresh cycle in the antagonist group were higher than those in the follicular phase prolonged protocol group(P<0.05).Conclusions For patients with normal ovarian response,using the early follicular phase prolonged protocol has a high clinical pregnancy rate and a low cancellation rate in the fresh transfer cycles,which is more beneficial for patients.However,there was no significant difference in pregnancy outcome between the two protocols for the first frozen embryo transfer after freeze-all.
作者
吕小晶
冯文娟
王凯
张迎春
LYU Xiaojing;FENG Wenjuan;WANG Kai;ZHANG Yingchun(Clinical Medical School,Weifang Medical University,Weifang,Shandong 261053,China;Department of Reproductive Medicine,Jinan Central Hospital,Jinan,Shandong 250013,China)
出处
《安徽医药》
CAS
2023年第7期1380-1385,共6页
Anhui Medical and Pharmaceutical Journal
关键词
排卵诱导
早卵泡期长效长方案
拮抗剂方案
体外受精-胚胎移植/卵胞浆内单精子注射
卵巢正常反应
临床结局
Ovulation induction
The early follicular phase prolonged protocol
GnRH antagonist protocol
In vitro fertilizationembryo transfer/intracytoplasmic sperm injection
Normal ovarian response
Clinical outcome
