摘要
目的建立妇产科专科生物样本库3.0版本。方法规范采集方式,从最初的只重数量的综合性采集转变为根据科研项目需求采取针对性采集为主、综合性采集为辅的模式;定期进行样本质量控制随机抽检,根据不同样本类型进行针对性的质量控制并完善相应的临床样本资料;严格把控样本出库申请流程并统计样本出库后的使用反馈。结果生物样本库3.0版本的建立整合了本院优势学科的临床资源,规范了临床样本的收集、储存和使用。样本库现储存妇科肿瘤样本14433例及妊娠合并疾病4233例,共接到获得伦理批准的申请80份,出库血液及组织样本约5382例,同时建成临床信息完善的样本信息库。生物样本库已参与本院的出生队列研究、出生缺陷研究、卵巢癌、宫颈癌及内膜癌的科研专项研究等多个科研项目。结论所建立的妇产科专科生物样本库3.0版本为推动医院的高质量发展、开展科学研究转化提供了坚实保障。
Objective To establish the obstetric and gynecologic biobank version 3.0.Methods The sample collection of the biobank was changed from the initial comprehensive collection to the mode of targeted collection based on the needs of research projects,and comprehensive collection as a supplement;the biobank conducted random sample quality control on a regular basis:carrying out targeted quality control according to different sample types and improving the corresponding clinical sample data;the biobank strictly controled the application process of sample delivery and recorded the statistical feedback after sample delivery.Results The establishment of biobank version 3.0 integrated the clinical resources of various dominant disciplines of the hospital and standardized the collection and storage of clinical samples.The biobank now stores 14433 cases of gynecological tumor samples and 4233 cases of pregnancy complicated diseases,and has received 80 ethical approval applications,provided about 5382 cases of blood and tissue samples for research of our hospital.Meanwhile,our biobank has also built a complete clinical information sample database.The biobank 3.0 has been participated in the birth cohort study,birth defect study,the research of ovarian cancer,cervical cancer,endometrial cancer and other special projects for many times.Conclusion The biobank 3.0 we established provides a solid guarantee to carry out scientific research transformation and high-quality development for the hospital.
作者
张赛
吴静
周佳宜
于焕镝
尹元
赵洪波
ZHANG Sai;WU Jing;ZHOU Jia-yi;YU Huan-di;YIN Yuan;ZHAO Hong-bo(The Biobank,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China;Department of Laboratory Medicine,Shanghai TCM-Integrated Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2023年第3期456-461,共6页
Fudan University Journal of Medical Sciences
关键词
生物样本库3.0
运营规划
可持续发展
妇产科
biobank 3.0
business planning
sustainable development
obstetrics and gynecology
