摘要
目的:针对舌下脱敏疗法治疗变应性鼻炎的机制与2型固有淋巴细胞(ILC2s)的相关性予以探究。方法:选取变应性鼻炎患者随机分为药物治疗组20例和药物联合脱敏治疗组20例,并以15例健康人作为对照组。检测治疗前后外周血及局部鼻腔灌洗液中损伤相关分子模式DAMPs(TSLP、IL-25)的表达,同时检测外周血中ILC2s及其效应因子(IL-13、IL-5、嗜酸性粒细胞阳离子蛋白)的水平。结果:变应性鼻炎患者DAMPs、ILC2s及其效应因子水平均显著高于对照组(P<0.05);与治疗前相比,联合治疗组的所有研究指标水平在治疗3个月后均显著降低(P<0.05),治疗1年后,联合治疗组中除DAMPs水平仍高于对照组(P<0.05);其余指标水平与对照组相比差异均无统计学意义(P>0.05)。结论:舌下脱敏疗法能调节变应性鼻炎患者过度活跃的ILC2s免疫应答,降低炎症反应,达到缓解和治疗变应性鼻炎的效果。
Objective:To explore the correlation between the mechanism of sublingual desensitization therapy in the treatment of allergic rhinitis and type 2 innate lymphocytes(ILC2s).Methods:Patients with allergic rhinitis were randomly divided into drug treatment group(20 cases)and drug combined desensitization treatment group(20 cases),and 15 healthy people were used as controls.The expressions of damage-associated molecular patterns(DAMPs)including TSLP and IL-25 in peripheral blood and local nasal lavage fluid,ILC2s and its related factors(IL-13,IL-5,eosinophil cationic protein)levels in peripheral blood were detected before and after treatment.Results:The levels of ILC2s and its related factors in peripheral blood of patients with allergic rhinitis were significantly higher than those in the control group(P<0.05);compared with before treatment,the levels of all research indexes in the combined treatment group were decreased significantly after 3 months of treatment(P<0.05).After 1 year of treatment,the level of DAMPs in the combined treatment group were still higher than those in the control group(P<0.05);the level of other indexes had no significant difference compared with the control group(P>0.05).Conclusion:Sublingual desensitization therapy can regulate the hyperactive ILC2s immune response in patients with allergic rhinitis,reduce the inflammatory response,and achieve the effect of alleviating and treating allergic rhinitis.
作者
龙海旺
童静
周磊
陈渝
柯霞
沈暘
王晓强
LONG Haiwang;TONG Jing;ZHOU Lei;CHEN Yu;KE Xia;SHEN Yang;WANG Xiaoqiang(Department of Ophthalmology and Otorhinolaryngology,Youyang Hospital,the First Affiliated Hospital of Chongqing Medical University,Chongqing 409800,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2023年第6期1295-1301,共7页
Chinese Journal of Immunology
基金
重庆市自然科学基金面上项目(cstc2019jcyj-msxmX0862)。
