摘要
吲哚-3-硫醚类化合物是一类重要的的生物活性分子,在医药以及农用化学品等领域具有广泛应用.如何通过简单、高效的方法构建此类结构单元,尤其是实现吲哚C-3原子上C-S键的选择性合成,已成为近年来高生物活性分子设计开发的重要手段.总结了通过吲哚3位C-H键直接选择性硫醚化制备吲哚-3-硫醚类化合物的方法,根据硫元素的不同来源对此类反应的研究进展进行综述.
3‑Sulfenylated indoles have been widely used in pharmaceutical and agrochemical industry due to their inherent potential biological activity.How to synthesize bioactive molecules containing such structural units via simple and efficient method,especially to achieve the selective construction of C-S bond on indole C-3 atom,has become an important means for the design and development of highly bioactive molecules in recent years.The recent development in the regioselective synthesis of 3-sulfenylated indoles via the direct sulfenylation of indoles at the C-3 position on the basis of different types of sulfenylating reagents is summarized.
作者
童宇星
王子维
刘奔
徐耀威
高颂
唐向兵
张兴华
Tong Yuxing;Wang Ziwei;Liu Ben;Xu Yaowei;Gao Song;Tang Xiangbing;Zhang Xinghua(China Tobacco Hubei Industrial Co.,Ltd.,Wuhan 430040;Hubei Xinye Reconstituted Tobacco Development Co.,Ltd,Wuhan 430056;Applied Technology Research of Reconstituted Tobacco Hubei Province Key Laboratory,Wuhan 430056;School of Chemical and Environmental Engineering,Shanghai Institute of Technology,Shanghai 201418)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2023年第4期1310-1324,共15页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21871182)资助项目。
关键词
硫醚化
C—S键
交叉偶联
sulfenylation
C-S bond
cross-coupling
