摘要
吲哚啉类化合物广泛存在于天然产物、药物和生物活性分子中,其结构多样性构建具有重要的意义.目前,吲哚的去芳构化转化已成为构建螺环、稠环、多取代吲哚啉类化合物的原子和步骤经济性途径.近年来,吲哚的去芳构化反应得到了不断发展,但对于C(2)=C(3)环内烯烃的串联去芳构化转化研究仍有较大的发展空间.基于此,聚焦迁移插入与自由基串联策略,详细总结了Pd、Ni、Co和Cu过渡金属催化的吲哚串联去芳构化转化,并探讨了相关的反应机理以及发展趋势.
Indolines are prevalent scaffolds of numerous natural products,pharmaceutical agents,and bioactive molecules,therefore,various strategies have been developed to access indolines.Indole dearomatization has been recognized as an important and straightforward strategy for constructing diverse functionalized indolines.Among a multitude of indoles dearomatization,the well-known strategies have relied on the inherent nucleophilicity of indole,while migratory insertion strategies for dearomatization have been widely applied in recent years.Herein,the recent advances of Pd,Ni,Co,Cu-catalyzed tandem dearomatizations of indoles via migratory insertion and radical-mediated process are summarized detailedly,and the mechanism and development tendency of this dearomatization reactions are discussed.
作者
庞明杨
常宏宏
冯璋
张娟
Pang Mingyang;Chang Honghong;Feng Zhang;Zhang Juan(College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024;School of Pharmaceutical Sciences,Chongqing University,Chongqing 401331)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2023年第4期1271-1291,共21页
Chinese Journal of Organic Chemistry
基金
山西省自然科学基金(No.20210302124123)资助项目。
关键词
过渡金属催化
吲哚
去芳构化
迁移插入
自由基串联
transition-metal-catalysis
indoles
dearomatization
migratory insertion
radical process
