摘要
目的 采用Meta分析方法评价钙离子载体辅助卵母细胞激活对患者妊娠结局的影响。方法 检索中国知网知识发现网络平台、维普中文期刊服务平台、万方数据知识服务平台、PubMed、Cochrane图书馆、Ebase数据库,搜集钙离子载体辅助卵母细胞激活对患者妊娠结局影响的随机对照试验(RCT)文献,检索时段从数据库建立到2022年10月。所有文献均由两位人员分别独立审阅、评价、抽取临床相关数据,使用RevMan5.4软件进行分析。结果 4篇RCT文献被纳入本研究,经分析在精子畸形或ICSI低受精的患者中,钙离子载体激活组的胚胎受精率、临床妊娠率和新生儿活产率显著高于对照组(P<0.05)。激活组的优胚率与对照组相差不大。结论 在精子畸形或ICSI低受精的患者中,钙离子载体辅助卵母细胞激活能提高其胚胎受精率,不影响受精后胚胎的发育,且能显著改善患者妊娠结局。
Objective To systematically evaluate the effect of calcium ionophore assisted oocyte activation on pregnancy outcome.Methods Randomized controlled trials(RCT)about effect of single and double intrauterine artificial insemination on pregnancy outcome of infertile patients were searched in the databases of CNKI,VIP,Wanfang,PubMed,Cochrane and Ebase from inception to October 2022.All literatures were selected,extracted and evaluated by two evaluators according to the inclusion and exclusion criteria,and then data was analysised by RevMan 5.4 software.Results A total of four RCT were finally included.The results of meta-analysis indicated that:The fertilization rate,clinical pregnancy rate and neonatal live birth rate in the calcium ionophore activated group were significantly higher than those in the control group in patients with sperm malformation or low ICSI fertilization(P<0.05).There was no significant difference in the rate of top quality embryos between the two groups.Conclusion In patients with sperm malformation or low ICSI fertilization in the previous cycle,calcium ionophore assisted oocyte activation can improve the fertilization rate of their embryos,not affect the development of embryos after fertilization,and can significantly improve the pregnancy outcome of patients.
作者
狄春光
王功发
华科
王毅
付伟平
DI Chunguang;WANG Gongfa;HUA Ke;WANG Yi;FU Weiping(Jiaxing Maternity and Child Health Care Hospital,Jiaxing,Zhejiang 314000,China)
出处
《中国优生与遗传杂志》
2023年第5期969-973,共5页
Chinese Journal of Birth Health & Heredity
关键词
钙离子载体
卵母细胞辅助激活
妊娠结局
calcium ionophore
assisted oocyte activation
pregnancy outcome
