摘要
Dear Editor,Variants of concern(VOCs)of SARS-CoV-2 have increased transmissibility,virulence,and resistance.The emergence of new VOCs continues to pose great challenges to public health.The detailed structures of the intact Omicron viruses remain unveiled.In this study,we report the architecture of both Omicron BA.1 and BA.2 lineages using cryo-electron tomography(cryo-ET).The subtomogram averaging of viral spikes,in both pre-fusion and postfusion conformations are also investigated.
基金
the Cryo-electron Microscopy Center,Southern University of Science and Technology,for their assistance with data collection.This work was supported by the National Natural Science Foundation of China(82070329 to Z.L.,82172240 to Y.W.,82025001 to J.Z.).
