摘要
A recent study by Brevini et al.was published in Nature and proposed a critical role of farnesoid X receptor(FXR)signaling in controlling ACE2 expression.Inhibitors of FXR signaling,ursodeoxycholic acid(UDCA)and z-guggulsterone(ZGG),have been proven to reduce ACE2 expression and susceptibility to SARS-CoV-2 infection in human tissues,providing an innovative strategy for SARS-CoV-2 treatment and prevention.
基金
the National Key R&D Program of China(2022YFA1105200)
the Chinese National Natural Science Funds(31870902,32070907,and 31871405)
the National Science Fund for Distinguished Young Scholars(32125016)
the Jiangsu National Science Foundation(19KJA550003).
