摘要
目的探讨健康孕妇不同孕期糖脂代谢指标的变化情况并建立参考区间。方法选取2020年1月至2020年6月郑州大学第三附属医院进行孕期检查的健康孕妇600例,根据孕期分类标准分为孕早期(≤12孕周),孕中期(13~28周),孕晚期A组(28~35周),孕晚期B组(36周~分娩前)各150例;另选择健康非妊娠女性150例为对照组。检测各组糖脂代谢指标。结果健康孕妇不同孕期血糖指标均低于对照组(P<0.05);孕中期组、孕晚期A组、孕晚期B组血糖指标均高于孕早期组(P<0.05);孕晚期B组参后2 h血糖(2 h PG)高于孕中期组、孕晚期A组(P<0.05);健康孕妇孕早期TC、LDL-C及孕中期LDL-C均低于对照组,其他不同孕期各项血脂指标均高于对照组(P<0.05);孕早期组、孕中期组、孕晚期A组、孕晚期B组TC、TG、LDL-C呈持续增高趋势,组间差异有统计学意义(P<0.05);空腹血糖(FPG)参考区间分别为3.51~4.85 mmol/L、3.88~5.06 mmol/L、3.86~5.12 mmol/L、3.76~5.28 mmol/L,2hPG参考区间为6.31~7.95 mmol/L、6.61~8.09 mmol/L、6.70~8.12 mmol/L、6.82~8.46 mmol/L,HbA1c参考区间为3.36%~5.36%、3.51%~5.55%、3.50%~5.62%、3.57%~5.65%,TG参考区间为2.98~5.44 mmol/L、3.47~6.09 mmol/L、3.52~7.00 mmol/L、3.27~8.09 mmol/L,TC参考区间为0.11~2.19 mmol/L、0.49~2.49 mmol/L、0.84~4.92 mmol/L、0.69~5.63 mmol/L,HDL-C参考区间为1.18~2.56 mmol/L、1.13~2.73 mmol/L、1.21~2.63 mmol/L、1.22~2.74 mmol/L,LDL-C参考区间为1.18~3.26 mmol/L、1.38~3.58 mmol/L、1.30~4.78 mmol/L、1.27~5.31 mmol/L。结论健康孕妇糖脂代谢指标参考区间与非妊娠女性存在差异,且不同孕期参考区间有所不同,建立健康孕妇不同孕期糖脂代谢指标参考区间,可为妊娠代谢综合征的早发现、早干预提供参考。
Objective To investigate the changes of glucose and lipid metabolism indexes in healthy pregnant women during different pregnancies and establish reference interval.Methods Totally 600 healthy pregnant women who underwent pregnancy examination in the Third Affiliated Hospital of Zhengzhou University from January 2020 to June 2020 were selected and divided into early pregnancy(≤12 gestational weeks),middle pregnancy(13-28 gestational weeks),late pregnancy group A(28-35 weeks)and late pregnancy group B(36 weeks to before delivery),150 cases each according to the classification standard of pregnancy.Another 150 healthy non-pregnant women were selected as control group.Glucose and lipid metabolism indexes of each group were detected.Results The blood glucose indexes of healthy pregnant women were lower than those of control group(P<0.05).The blood glucose indexes of the second trimester group,the third trimester group A and the third trimester group B were higher than those of the first trimester group(P<0.05).2hPG of group B in the third trimester was higher than that of group A in the second trimester and the third trimester(P<0.05).TC,LDL-C and LDL-C in the first and second trimesters of healthy pregnant women were lower than those of control group,and other lipid indexes in pregnancy were higher than those of control group(P<0.05).TC,TG and LDL-C in the four groups showed a trend of continuous increase,with statistical significance(P<0.05).The FPG reference ranges of early,middle and late pregnancy(28-35 weeks)and late pregnancy(36 weeks later)were 3.51 to 4.85 mmol/L,3.88 to 5.06 mmol/L,3.86 to 5.12 mmol/L,3.76 to 5.28 mmol/L.The reference interval of 2hPG were 6.31~7.95 mmol/L,6.61~8.09 mmol/L,6.70-8.12 mmol/L,6.82-8.46 mmol/L.HbA1c reference interval were 3.36%-5.36%,3.51%-5.55%,3.50%-5.62%,3.57%-5.65%,the TG reference interval were 2.98-5.44 mmol/L,3.47-6.09 mmol/L,3.52-7.00 mmol/L,3.27-8.09 mmol/L.TC reference interval were 0.11-2.19 mmol/L,0.49-2.49 mmol/L,0.84-4.92 mmol/L,0.69-5.63 mmol/L,The HDL-C refer
作者
吕忠兴
耿世林
王竹园
邢金芳
LYU Zhong-xing;GENG Shi-lin;WANG Zhu-yuan;XING Jin-fang(Laboratory Department of the Third Affiliated Hospital of Zhengzhou University,Zhenghzou 450000,China)
出处
《医药论坛杂志》
2023年第8期12-15,共4页
Journal of Medical Forum
基金
河南省医学科技攻关计划联合共建项目(LHGJ20190398)。
关键词
血糖
血脂
妊娠
代谢综合征
参考区间
Blood sugar
Blood fat
Pregnancy
Metabolic syndrome
Reference interval
