摘要
目的探究超声内镜辅助内镜黏膜下剥离术治疗早期食管癌及癌前病变的临床效果。方法选取2019年4月—2022年3月靖江市人民医院收治的68例早期食管癌及癌前病变患者为研究对象,采用随机数表法分为对照组、观察组,各34例。对照组接受常规内镜黏膜下剥离术治疗;观察组接受超声内镜辅助内镜黏膜下剥离术治疗,对比两组治疗后的手术相关临床指标、生理应激反应指标水平、肿瘤标志物指标水平、术中不良事件及并发症发生情况。结果治疗后,观察组病灶一次性完整切除率为100.00%,其手术时长及住院时长分别为(27.16±3.59)min、(7.10±0.79)d均明显优于对照组,差异有统计学意义(χ^(2)=4.570,t=14.083、4.275,P<0.05)。观察组治疗后去甲肾上腺素、肾上腺素指标水平分别为(101.19±11.64)ng/mL、(80.64±4.10)ng/mL均低于对照组,差异有统计学意义(t=14.734、22.649,P<0.05)。观察组的DDK-1(40.64±5.37)ng/mL、SCC-Ag(0.34±0.05)ng/mL、Cyfra21-1(6.19±1.04)ng/mL水平均低于对照组,差异有统计学意义(t=15.514、20.955、14.344,P<0.05)。观察组治疗后的术中出血、术中穿孔及食管狭窄并发症发生率分别为2.94%、0.00%、2.94%均明显优于对照组,差异有统计学意义(χ^(2)=4.610、4.570、4.610,P<0.05)。结论超声内镜辅助内镜黏膜下剥离术治疗早期食管癌及癌前病变的临床效果较为显著,可明显提升手术有效性及术后康复质量,同时可明显减少手术相关生理应激反应及术后并发症,显著降低肿瘤标志物指标水平。
Objective To investigate the clinical effect of endoscopic ultrasound assisted submucosal dissection in the treatment of early esophageal cancer and precancerous lesions.Methods 68 patients with early esophageal cancer and precancerous lesions admitted to Jingjiang People's Hospital from April 2019 to March 2022 were selected as the study subjects.They were randomly divided into control group and observation group,with 34 cases each.The control group received conventional endoscopic submucosal dissection.The observation group received the treatment of endoscopic submucosal dissection assisted by ultrasound,and compared the clinical indicators related to surgery,the level of physiological stress response indicators,the level of tumor markers,adverse events and complications during operation between the two groups.Results After treatment,the one-time complete resection rate of the focus in the observation group was 100.00%,and the operation duration and hospitalization duration were(27.16±3.59)min and(7.10±0.79)d respectively,which were significantly better than those in the control group(χ^(2)=4.570,t=14.083,4.275,P<0.05).After treatment,the levels of,norepinephrine and epinephrine in the observation group were(101.19±11.64)ng/mL and(80.64±4.10)ng/mL,respectively,lower than those in the control group,and the difference was statistically significant(t=14.734,22.649,P<0.05).The levels of DDK-1(40.64±5.37)ng/mL,SCC-Ag(0.34±0.05)ng/mL,Cyfra21-1(6.19±1.04)ng/mL in the observation group were significantly lower than those in the control group,and the difference was statistically significant(t=15.514,20.955,14.344,P<0.05).The complication rates of intraoperative hemorrhage,intraoperative perforation and esophageal stricture in the observation group after treatment were 2.94%,0.00%and 2.94%respectively,which were significantly higher than those in the control group,and the difference was statistically significant(χ^(2)=4.610,4.570,4.610,P<0.05).Conclusion Endoscopic ultrasound assisted submucosal dissection for t
作者
秦幼娟
沙杰
朱明辉
巢烨
QIN Youjuan;SHA Jie;ZHU Minghui;CHAO Ye(Department of Gastroenterology,Jingjiang People's Hospital,Jingjiang,Jiangsu Province,214500 China)
出处
《世界复合医学》
2023年第2期107-110,共4页
World Journal of Complex Medicine
关键词
超声内镜辅助内镜黏膜下剥离术
早期食管癌
癌前病变
Endoscopic ultrasound assisted endoscopic submucosal dissection
Early esophageal cancer
Precancerous lesion
