摘要
目的:观察苯磺酸瑞马唑仑在肥胖患者无痛胃镜检查中的临床效果。方法:选取2021年5月-2022年5月于中国人民解放军联勤保障部队第九〇〇医院行无痛胃镜检查的肥胖患者,共80例。随机分为两组:丙泊酚组(P组)和苯磺酸瑞马唑仑组(R组),各40例。患者检查前均静脉给予舒芬太尼0.1μg/kg,3 min后P组给予丙泊酚2 mg/kg静脉麻醉,R组给予苯磺酸瑞马唑仑0.25 mg/kg静脉麻醉。记录两组麻醉诱导前(T_(0))、胃镜到达咽喉部时(T_(1))、胃镜到达咽喉部后3 min(T_(2))、胃镜检查结束时(T_(3))的平均动脉压(MAP)、心率(HR)和脉搏血氧饱和度(SpO_(2));记录两组起效时间、苏醒时间、离室时间及不良事件的发生情况。结果:两组T_(0)的MAP、HR、SpO_(2)比较,差异均无统计学意义(P>0.05);T_(1)、T_(2)、T_(3),R组MAP、HR均高于P组;T_(1)、T_(2),R组SpO_(2)均高于P组(P<0.05);两组T_(3)的SpO_(2)比较,差异无统计学意义(P>0.05)。两组起效时间比较,差异无统计学意义(P>0.05),R组苏醒和离室时间均短于P组(P<0.05)。R组低氧血症、低血压、嗜睡、头晕、注射痛发生率均明显低于P组(P<0.05);两组体动、恶心呕吐发生率比较,差异均无统计学意义(P>0.05)。结论:苯磺酸瑞马唑仑应用于肥胖患者无痛胃镜检查中,对患者呼吸循环影响较小,不良事件的发生率较低,可以提高麻醉的安全性。
Objective:To observe the clinical effect of Remimazolam Besylate in painless gastroscopy of obese patients.Method:A total of 80 obese patients who underwent painless gastroscopy in the 900 Hospital of the Joint Service Support Force of the People's Liberation Army of China from May 2021 to May 2022 were selected.They were randomly divided into two groups:Propofol group(P group)and Remimazolam Besylate group(R group),with 40 cases in each group.All patients were given Sufentanil 0.1μg/kg intravenously before examination,3 min later,patients in P group were given intravenous anesthesia with 2 mg/kg Propofol,and patients in R group were given intravenous anesthesia with 0.25 mg/kg Remimazolam Besylate.The mean arterial pressure(MAP),heart rate(HR),and pulse oxygen saturation(SpO_(2))of the two groups were recorded before anesthesia induction(T_(0)),at the time of gastroscope reaches the throat(T_(1)),3 min after gastroscope reaches the throat(T_(2)),and at the end of gastroscopy(T_(3)).The onset time,awakening time,departure time and adverse events in the two groups were recorded.Result:There were no significant differences in MAP,HR and SpO_(2)between the two groups at T_(0)(P>0.05).At T_(1),T_(2)and T_(3),the MAP and HR of R group were higher than those of P group,and at T_(1),T_(2),the SpO_(2)in R group were higher than those in P group(P<0.05).There was no significant difference in SpO_(2)between the two groups at T_(3)(P>0.05).There was no significant difference in onset time between the two groups(P>0.05),and the time of awakening and departure in R group were shorter than those in P group(P<0.05).The incidences of hypoxemia,hypotension,lethargy,dizziness and injection pain in R group were significantly lower than those in P group(P<0.05).There were no significant differences in the incidence of body movement,nausea and vomiting between the two groups(P>0.05).Conclusion:The application of Remimazolam Besylate in painless gastroscopy of obese patients has little influence on the respiratory and circulatory sys
作者
陈亨道
肖锦容
黄滨
CHEN Hengdao;XIAO Jinrong;HUANG Bin(The 900 Hospital of the Joint Service Support Force of the People's Liberation Army of China,Fuzhou 350025,China;不详)
出处
《中国医学创新》
CAS
2023年第14期38-42,共5页
Medical Innovation of China
