摘要
目的:探究重症急性胰腺炎患者应用艾司奥美拉唑及奥曲肽治疗对炎症因子及血乳酸水平的影响。方法:将2021年6月-2022年7月在樟树市人民医院治疗的60例重症急性胰腺炎患者采用随机数字表法分为两组,每组30例。入组后,两组患者均给予基础治疗,对照组给予艾司奥美拉唑治疗,观察组在对照组基础上加用奥曲肽治疗,均连续治疗2个疗程。观察两组恢复情况,对比两组临床疗效、炎症因子水平[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、血乳酸正常率。结果:观察组总有效率为83.33%(25/30),明显高于对照组的56.67%(17/30),差异有统计学意义(P<0.05);观察组腹胀痛消失时间,肠鸣音及血、尿淀粉酶恢复正常时间均短于对照组,差异均有统计学意义(P<0.05);治疗后,观察组CRP、IL-6、TNF-α水平均较对照组低,差异均有统计学意义(P<0.05);治疗后,观察组血乳酸正常率(83.33%)明显高于对照组(43.33%),差异有统计学意义(P<0.05)。结论:艾司奥美拉唑及奥曲肽联合应用于重症急性胰腺炎可提高治疗效果,有效降低炎症因子水平,恢复血乳酸水平。
Objective:To investigate the effects of Esomeprazole Magnesium and Octreotide on inflammatory factors and blood lactic acid level in patients with severe acute pancreatitis.Method:A total of 60 patients with severe acute pancreatitis treated in Zhangshu People's Hospital from June 2021 to July 2022 were divided into two groups according to random number table method,with 30 cases in each group.After entering the group,the patients in both groups were given basic treatment.The control group was treated with Esomeprazole Magnesium,and the observation group was treated with Octreotide on the basis of the control group,both of which were received two courses of continuous treatment.The recovery of the two groups were observed.The clinical efficacy,the levels of inflammatory factors[C reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],and normal rate of blood lactic acid were compared between the two groups.Result:The total effective rate of the observation group was 83.33%(25/30),which was significantly higher than that of the control group 56.67%(17/30),the difference was statistically significant(P<0.05).The disappearance time of abdominal distension pain,the return to normal time of borborygmus and blood,urine amylase in the observation were shorter than those in the control group(P<0.05).After treatment,the levels of CRP,IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).After treatment,the normal rate of blood lactic acid in the observation group(83.33%)was significantly higher than that in the control group(43.33%),the difference was statistically significant(P<0.05).Conclusion:The combination of Esomeprazole Magnesium and Octreotide in severe acute pancreatitis can improve the therapeutic effect,effectively reduce inflammatory factors and restore blood lactic acid level.
作者
张佑红
ZHANG Youhong(Zhangshu People's Hospital,Jiangxi Province,Zhangshu 331200,China)
出处
《中国医学创新》
CAS
2023年第15期26-29,共4页
Medical Innovation of China
基金
江西省卫生健康委科技计划项目(20202054)。
关键词
重症急性胰腺炎
艾司奥美拉唑
奥曲肽
炎症因子
血乳酸
Severe acute pancreatitis
Esomeprazole Magnesium
Octreotide
Inflammatory factors
Blood lactic acid
