摘要
目的探讨淋巴细胞/单核细胞比值(LMR)在多发性骨髓瘤(MM)患者预后中的预测价值。方法选择197例MM患者,测定LMR值,绘制ROC确定LMR的最佳临界值,按照LMR最佳临界值分为高LMR组(104例)和低LMR组(93例),分析LMR水平与临床病理特征的相关性,然后利用Log-rank方法比较不同LMR水平的MM患者无进展生存时间(PFS)的差异。结果通过ROC曲线确定LMR预测生存的最佳临界值为3.55,不同LMR水平患者的血清乳酸脱氢酶、ISS分期和血钙比较,差异均有统计学意义(χ^(2)分别=17.10、17.72、4.38,P均<0.05)。高LMR患者PFS高于低LMR水平的患者,差异有统计学意义(χ^(2)=6.69,P<0.05)。结论高LMR的患者PFS较低LMR的患者高,低LMR可能是MM患者预后不良的因素。
Objective To explore the prognostic value of lymphocyte to monocyte ratio(LMR)in patients with multi⁃ple myeloma(MM).Methods Totally 197 patients with MM were selected and their LMR level were detected.ROC was plotted to determine the optimal threshold of LMR.According to the optimal threshold for LMR,they were divided in⁃to high LMR group(104 cases)and low LMR group(93 cases).The correlation between LMR levels and clinicopatholog⁃ical characteristics was analyzed.Then,the Log rank method was used to compare the difference in PFS between different LMR levels of MM patients.Results The optimal threshold for predicting survival by LMR was determined by the ROC curve to be 3.55.The serum lactate dehydrogenase,ISS stage,and blood calcium in patients with multiple myeloma be⁃tween high LMR group and low LMR group(χ^(2)=17.10,17.72,4.38,P<0.05).Patients with high LMR have a higher PFS than low LMR(χ^(2)=6.69,P<0.05).Conclusion Patients with high LMR have a higher PFS compared to patients with low LMR.Low LMR may be a poor prognostic factor for MM patients.
作者
梁冬萍
徐祥剑
杨绍雪
LIANG Dongping;XU Xiangjian;YANG Shaoxue(Department of Hematology,Affiliated Xinchang Hospital,Wenzhou Medical University,Xinchang 312500,China)
出处
《全科医学临床与教育》
2023年第5期395-397,406,共4页
Clinical Education of General Practice
基金
浙江省医药卫生科技项目(2021KY081、2022KY671)。
