摘要
头孢类抗生素是临床上治疗细菌感染的常用药物,但耐药问题日益严重,亟需研发对耐药致病菌有效的抗感染药物。本文对近15年FDA批准上市的头孢类药物品种进行总结,主要介绍抗菌谱、抗菌活性和临床应用范围,并对活性成分(API)的化学结构优化结果与抗菌活性关系进行简要介绍,希望对国内新型抗生素药物的正确使用和研发有所帮助。
The development of new anti-infective drugs with new targets and different mechanisms of action has become a hot spot,but the progress is slow and the inhibitor activity is not satisfactory.Cephalosporins are commonly used in the treatment of bacterial infections,but the problem of drug resistance is becoming more and more serious.It is urgent to develop effective anti-infective drugs against drug-resistant pathogens.Cephalosporins on the market in recent years are all sensitive to drug-resistant bacteria.In this paper,the cephalosporins approved by FDA in recent 15 years were summarized.The chemical structure,composition evolution of active pharmaceutical ingredient(API),and its influence on antibacterial activity and antibacterial spectrum were briefly introduced.It was hoped that it would provide some enlightenment for the research and development of new antibiotics in China.
作者
黄玮
甄丹宁
徐松林
付德才
Huang Wei;Zhen Dan-ning;Xu Song-lin;Fu De-cai(College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018)
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2023年第4期368-373,共6页
Chinese Journal of Antibiotics
