摘要
在人体中,存在着一种围绕着除脑血管外的所有心血管的脂肪组织,称为血管周围脂肪(perivascular adipose tissue,PVAT)。近年来,由于其位置及功能的特殊性,PVAT被视为一种不同于传统内脏脂肪的新型脂肪组织,可通过旁分泌、内分泌具有促进血管舒缩功能的脂肪因子,介导免疫炎症反应及脂肪细胞表型转换等途径,对心血管系统产生双面性的影响,包括在生理状态下对心血管的保护作用及病理状态下促心血管疾病(cardiovascular disease,CVD)发生的不良作用。而通过对PVAT的实验室及影像学检查与干预,有助于提高对心血管疾病的诊断能力、增加具有可行性的治疗手段。本文将叙述PVAT与经典脂肪类型的区别,其生理、病理情况下对心血管系统的影响及在心血管疾病诊疗中的作用。
For the past few years,a unique type of adipose tissue,surrounding our cardiovascular system but cerebrovascular,known as perivascular adipose tissue(PVAT),has been seen as a new kind of adipose tissue different from the classic visceral fat due to its unusual anatomic location and function.PVAT exerts a bidirectional effect on the cardiovascular system,including the protectional role under physiological state and the deleterious influence under pathological state,through the release of vasoconstrictive/relaxant adipokine in a paracrine/endocrine manner,the induction of inflammation and phenotypic transformation of adipocytes.PVAT also shows a potential role in the diagnosis and treatment of cardiovascular disease(CVD)as a new parameter and intervention.In this review,we will discuss the characteristics of PVAT to distinguish from classic adipose tissue and its effect on CVD under physiology/pathology conditions,also,its application in CVD diagnosis and treatment.
作者
张文娜
朱浩
王晓东
ZHANG Wenna;ZHU Hao;WANG Xiaodong(Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报（自然科学版）》
CAS
北大核心
2023年第5期725-731,共7页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省卫生健康委员会基金(BJ20013)。
关键词
肥胖
脂肪
血管周围脂肪
心血管疾病
冠状动脉粥样硬化
腹主动脉瘤
obesity
adipose tissue
perivascular adipose tissue
cardiovascular disease
coronary atherosclerosis
abdominal aortic aneurysm
