摘要
目的:比较临床中调强放疗与三维适形放疗治疗子宫颈癌的效果。方法:选择2020年4月—2022年4月安溪县医院收治62例子宫颈癌患者作为研究对象,根据随机数表法将其分成对照组(三维适形放疗)和试验组(调强放疗),各31例。比较两组治疗后的疾病控制率、不良反应、肿瘤标志物、血清指标。结果:试验组疾病控制率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原724(CA724)、鳞状上皮抗原(SCCA)水平比较,差异无统计学意义(P>0.05);治疗后,两组CEA、CA199、CA724、SCCA水平均明显低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组基质金属蛋白酶9(MMP-9)、血管内皮生长因子C(VEGFC)、恶性肿瘤特异性生长因子(TSGF)、转化生长因子β_(1)(TGF-β_(1))水平比较,差异无统计学意义(P>0.05);治疗后,两组MMP-9、VEGFC、TSGF、TGF-β_(1)水平均低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。结论:子宫颈癌临床治疗中调强放疗与三维适形放疗均可获得一定治疗效果,但调强放疗的疾病控制率更高,患者肿瘤标志物、血清指标改善效果更好,放疗安全性两者相当。
Objective:To compare the effect of intensity modulated radiotherapy and three-dimensional conformal radiotherapy in the treatment of cervical cancer.Method:A total of 62 cases of cervical cancer patients admitted to Anxi County Hospital from April 2020 to April 2022 were selected as the research subjects,they were divided into control group(three-dimensional conformal radiotherapy)and experimental group(intensity modulated radiotherapy)by random number table method,with 31 cases in each group.The disease control rate,adverse reactions,tumor markers,and serum indicators between the two groups after treatment were compared.Result:The disease control rate in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no statistically significant differences in the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 724(CA724),and squamous cell carcinoma antigen(SCCA)between the two groups(P>0.05);after treatment,the levels of CEA,CA199,CA724,and SCCA in the two groups were significantly lower than those before treatment,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in levels of matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor C(VEGFC),tumor specific growth factor(TSGF)and transforming growth factor-β_(1)(TGF-β_(1))between the two groups(P>0.05);after treatment,all levels of MMP-9,VEGFC,TSGF,TGF-β_(1) in the two groups were lower than those before treatment,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Both intensity modulated radiotherapy and three-dimensional conformal radiotherapy can achieve ce
作者
陈凯婧
CHEN Kaijing(Anxi County Hospital,Anxi 362400,China)
出处
《中外医学研究》
2023年第15期136-139,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
子宫颈癌
三维适形放疗
调强放疗
Cervical cancer
Three-dimensional conformal radiotherapy
Intensity modulated radiotherapy
