摘要
目的:探究动态血糖监测的准确性及血糖波动与低血糖的关系。方法:选取91例糖尿病患者作为研究对象,所有患者佩戴5 d动态血糖监测系统(CGMS)测定各个时段的血糖水平。使用Bland-Altman分析评估动态血糖监测在各个时段监测血糖的准确性。应用Logistic回归分析确定影响患者发生低血糖的危险因素,并绘制ROC曲线评价血糖波动对糖尿病患者发生低血糖的预测价值。结果:动态血糖监测空腹时段、餐后时段、平均水平的偏倚值及一致限度分别为0.219(-4.297~3.860)、0.189(-4.919~5.296)、0.283(-7.285~7.851)。高血糖标准差(SDBG)、平均血糖值(MBG)、糖化血红蛋白(GHb)水平是影响糖尿病患者并发低血糖的危险因素(P<0.05)。SDBG预测糖尿病患者发生低血糖的敏感度、特异度、约登指数分别为91.43%、80.00%、0.714。结论:CGMS可较为准确的反映糖尿病患者的血糖变化,SDBG是患者发生低血糖的危险因素。
Objective:To explore the accuracy of continuous blood glucose monitoring and the relationship between blood glucose fluctuations and hypoglycemia.Methods:A total of 91 diabetic patients were selected as the research subjects,and all patients were equipped with a 5 d continuous blood glucose monitoring system(CGMS)to measure the blood glucose levels in various periods.Bland-Altman analysis was used to evaluate the accuracy of continuous blood glucose monitoring in monitoring blood glucose in each time period.Logistic regression analysis were used to identify the risk factors affecting the occurrence of hypoglycemia,and the ROC curve was used to evaluate the predictive value of blood glucose fluctuations for hypoglycemia in diabetic patients.Results:The bias value and agreement limit of the fasting period,postprandial period,and average level of continuous blood glucose monitoring were 0.219(-4.297~3.860),0.189(-4.919~5.296),0.283(-7.285~7.851).High standard deviation of blood glucose(SDBG),mean blood glucose(MBG)and glycosylated hemoglobin(GHb)level were risk factors for patients with diabetes complicated with hypoglycemia(P<0.05).The sensitivity,specificity and Youden index of SDBG in predicting hypoglycemia in diabetic patients were 91.43%,80.00%,and 0.714,respectively.Conclusion:The accuracy of continuous blood glucose monitoring is considerable,and CGMS can more accurately reflect the blood sugar changes in diabetes.
作者
李梓
李丹丹
LI Zi;LI Dan-dan(Department of Endocrinology,Bengbu First People's Hospital,Bengbu 233000,Anhui,China;Department of General Medicine,Bengbu First People's Hospital,Bengbu 233000,Anhui,China)
出处
《川北医学院学报》
CAS
2023年第5期665-667,680,共4页
Journal of North Sichuan Medical College
基金
安徽省蚌埠市科技局项目(20170320)。
关键词
动态血糖监测
血糖波动
准确性
关联性
Continuous blood glucose testing
Blood sugar fluctuations
Accuracy
Relevance
