摘要
中医药在治疗慢性肾脏病矿物质和骨代谢异常(CKD-MBD)具有一定优势,近年来出现许多中药复方及中药单体治疗CKD-MBD的研究。通过文献检索发现,中药治疗CKD-MBD相关通路的机制研究中,以中药自拟复方研究为主,作用途径涉及纤维细胞生长因23/Klotho(FGF23/Klotho)信号通路、Wnt/β-连环蛋白(Wnt/β-catenin)信号通路、核转录因子-κB受体活化因子/核转录因子-κB受体活化因子配体/骨保护素(RANK/RANKL/OPG)系统等多条信号通路,中药能通过调节此系列信号通路改善钙磷代谢、骨代谢紊乱、调控炎症反应、氧化应激、细胞凋亡和自噬,从而治疗CKD-MBD。该文将对这些信号通路和中药治疗CKD-MBD在作用机制领域取得的研究成果进行介绍,以期为中药治疗CKD-MBD的相关研究提供思路和参考。
Traditional Chinese medicine(TCM) has certain advantages in the treatment of chronic kidney disease-mineral and bone disorder(CKD-MBD).In recent years,there have been many studies on the treatment of CKD-MBD by Chinese medicinal compounds and monomers.As revealed by literature retrieval,the research on the mechanism of Chinese medicine in intervening in signaling pathways related to CKD-MBD was mainly based on self-made Chinese medicinal compounds,and the action pathways involved fibroblast growth factor 23/Klotho(FGF23/Klotho) signaling pathway,Wnt/β-catenin signaling pathway,receptor activator of nuclear factor-κB/receptor activator of nuclear factor-κB ligand/osteoprotegerin(RANK/RANKL/OPG) system,and other signaling pathways.TCM can improve calcium and phosphorus metabolism and bone metabolism disorder,and regulate inflammatory reaction,oxidative stress,apoptosis,and autophagy by regulating this series of signaling pathways for the treatment of CKD-MBD.This paper introduced the research results of these signaling pathways and the mechanism of TCM in the treatment of CKD-MBD in order to provide ideas and references for the related research of Chinese medicine in the treatment of CKD-MBD.
作者
郭星云
张宁
柳诗意
GUO Xingyun;ZHANG Ning;LIU Shiyi(Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第12期248-256,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中国中医科学院科技创新工程重大攻关项目(C12021A01609)
国家自然科学基金青年基金项目(81904156)
中央级公益性科研院所基本科研业务费专项(ZZ14-YQ-021)。
