摘要
Hippo信号通道介导细胞内外信号传递,其调节细胞增殖、分化、凋亡进程,可在骨代谢、脂代谢及血管新生等方面发挥作用。故该通道可能对非创伤性股骨头坏死发病机制有重要意义。本文主要通过Hippo通道相关蛋白结构、功能在骨代谢、脂代谢及血管新生方面的作用机制进行探讨,寻找其在NONFH中的作用机制,从而为NONFH提供新的临床研究靶点。
Hippo signaling pathway mediates signal transmission inside and outside cells,which regulates the process of cell prolifera⁃tion,differentiation and apoptosis,and playes role in bone metabolism,lipid metabolism and angiogenesis.Therefore,this pathway may be of great significance in the pathogenesis of non-traumatic femoral head necrosis.This paper mainly discusses the mechanism of Hippo path⁃way related protein structure and function in bone metabolism and lipid metabolism,and looks for its mechanism in NONFH to provide a new clinical research target for NONFH.
作者
黄克松
王晓萍
柳海平
周明旺
HUANG Ke-song;WANG Xiao-ping;LIU Haiping;ZHOU Ming-wang(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2023年第8期714-718,共5页
Orthopedic Journal of China
基金
国家自然科学基金地区科学基金项目(编号:8186150551,82060876)
甘肃中医药大学2022年研究生创新创业基金项目(编号:2022CX25)。
关键词
Hippo信号通道
股骨头坏死
骨代谢
脂代谢
血管新生
Hippo signaling pathway
femoral head necrosis
bone metabolism
lipid metabolism
angiogenesis
