摘要
目的探讨影响儿童朗格汉斯细胞组织细胞增生症(LCH)预后的危险因素。方法回顾性分析121例LCH患儿的临床资料,采用log-rank检验分析LCH患儿的年龄、性别、临床分类、重要器官受累情况、是否规律化疗与患儿生存时间的关系,并采用COX回归模型分析影响LCH患儿预后的危险因素。结果性别、是否存在中枢神经系统受累均与LCH患儿的生存时间无相关性(均P>0.05);而年龄、是否存在血液系统受累、是否存在脾脏受累、是否存在肝脏受累、是否存在肺脏受累、是否存在骨组织受累、临床分类及是否规律化疗均与LCH患儿的生存时间有相关性(均P<0.05)。COX回归分析结果显示,年龄≤2岁、性别为男、血液系统受累、未规律化疗均是影响LCH患儿预后的独立危险因素(均P<0.05)。结论年龄≤2岁、性别为男、伴有血液系统受累及未规律化疗的LCH患儿生存时间更短,预后更差,临床上应该重点关注该类患儿,及时制订个体化治疗方案并正确评估预后。
Objective To explore the risk factors in affecting the prognosis of children with Langerhans cell histiocytosis(LCH).Methods The clinical data of 121 LCH children were retrospectively analyzed.The relation of LCH children′s age,gender,clinical classification,involvement of vital organs,and the presence of regular chemotherapy with children′s survival time was analyzed by using the log-rank test.The risk factors in affecting LCH children′s prognosis were analyzed by employing COX regression model.Results No correlation was found between gender,the presence of central nervous system involvement and LCH children′s survival time(all P>0.05),whereas age,and the presence of involvement of blood system,spleen involvement,liver involvement,lung involvement,bone tissue involvement,as well as clinical classification,the presence of regular chemotherapy indicated a correlation with LCH children′s survival time(all P<0.05).The results of COX regression analysis interpreted that age≤2 years old,male,blood system involvement,non-regular chemotherapy were the independent risk factors in affecting LCH children′s prognosis(all P<0.05).Conclusion LCH children with age≤2 years old,whose gender is male,with blood system involvement and non-regular chemotherapy have shorter survival time and poorer prognosis,which indicated that more attention should be paid to these children,and individualized therapeutic regimens should be made in time and the prognosis should be evaluated correctly in clinic.
作者
赵巍
何云燕
ZHAO Wei;HE Yunyan(Graduate School,Guangxi Medical University,Nanning 530021,Guangxi,China;Department of Pediatrics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China)
出处
《广西医学》
CAS
2023年第7期765-768,778,共5页
Guangxi Medical Journal
