摘要
目的:系统评价针灸治疗烟草戒断综合征的疗效。方法:计算机检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、中国生物医学文献数据库(Sino Med)、Pub Med、Cochrane、Medline及EMbase数据库中针灸治疗烟草戒断综合征的随机对照试验(RCT)文献,检索时限为2011年1月1日至2021年12月31日。对纳入文献进行资料提取和偏倚风险评价后,采用RevMan5.4.1软件进行Meta分析。结果:共纳入RCT文献23篇,共2120例患者,Meta分析结果显示:与药物比较,针灸在改善尼古丁依赖量表(FTND)评分[MD=0.16,95%CI(-0.08,0.41)]、吸烟强度指数量表(HSI)评分[MD=0.11,95%CI(-0.13,0.36)]、明尼苏达尼古丁戒断量表(MNWS)评分[MD=0.12,95%CI(-1.11,1.35)]、吸烟渴求简短问卷(QSU)评分[MD=-0.30,95%CI(-2.78,2.18)]、汉密尔顿抑郁量表(HAMD)评分[MD=0.76,95%CI(-1.54,3.06)]及提高戒断率[RR=0.95,95%CI(0.82,1.10)]和有效率[RR=1.01,95%CI(0.95,1.07)]方面差异无统计学意义(P>0.05);针灸在降低MNWS评分[MD=-4.88,95%CI(-5.21,-4.55)]方面优于假针灸(P<0.00001);针灸在降低FTND评分[MD=-1.41,95%CI(-1.74,-1.08)]、MNWS评分[MD=-4.28,95%CI(-5.31,-3.25)]及提高戒断率[RR=2.19,95%CI(1.39,3.45)]方面优于认知行为疗法(P<0.00001,P<0.001)。结论:针灸可有效改善烟草戒断综合征,提高戒断率和有效率。受纳入研究数量和质量的限制,上述结论尚需要开展更多研究予以验证。
Objective To systematically review the efficacy of acupuncture for the treatment of tobacco withdrawal syndrome.Methods The randomized controlled trials(RCTs)regarding acupuncture for treatment of tobacco withdrawal syndrome were searched in CNKI,Wanfang,VIP,SinoMed,PubMed,Cochrane,Medline and EMbase databases.The search period was from January 1st of 2011 to December 31st of 2021.After data extraction and bias risk assessment of the included literature,the Meta-analysis was performed using RevMan5.4.1 software.Results Totally 23 RCTs were included,including 2120 patients.The Meta-analysis results showed that compared with medication,acupuncture showed no significant difference at improving Fagerström test for nicotine dependence(FTND)score(MD=0.16,95%CI:-0.08,0.41),heaviness of smoking index(HSI)score(MD=0.11,95%CI:-0.13,0.36),Minnesota nicotine withdrawal scale(MNWS)score(MD=0.12,95%CI:-0.11,1.35),questionnaire of smoking urges(QSU)score(MD=-0.30,95%CI:-2.78,2.18),Hamilton depression scale(HAMD)score(MD=0.76,95%CI:-1.54,3.06),abstinence rate(RR=0.95,95%CI:0.82,1.10)and effective rate(RR=1.01,95%CI:0.95,1.07).Acupuncture was superior to sham acupuncture in reducing MNWS score(MD=-4.88,95%CI:-5.21,-4.55,P0.00001).Acupuncture was superior to cognitive behavioral therapy in reducing FTND score(MD=-1.41,95%CI:-1.74,-1.08),MNWS score(MD=-4.28,95%CI:-5.31,-3.25)and increasing abstinence rate(RR=2.19,95%CI:1.39,3.45,P0.00001,P<0.001).Conclusion Acupuncture could effectively improve tobacco withdrawal syndrome,increase abstinence rate and effective rate.Limited by the quantity and quality of the included studies,this conclusion needs to be verified by more studies.
作者
刘振宇
陈淑敏
畅金
王莹莹
杨金生
LIU Zhen-yu;CHEN Shu-min;CHANG Jin;WANG Ying-ying;YANG Jin-sheng(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Basic Theory of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences)
出处
《中国针灸》
CAS
CSCD
北大核心
2023年第5期575-583,590,共10页
Chinese Acupuncture & Moxibustion
基金
中国中医科学院科技创新工程项目:CI2021A03506
中国中医科学院针灸研究所自主选题项目:ZZ202017014
中国中医科学院“一带一路”项目:GH201922
首都卫生发展科研专项重点攻关项目:2022-1-4281。
关键词
烟草戒断综合征
针灸
系统评价
META分析
随机对照试验
tobacco withdrawal syndrome
acupuncture
systematic review
Meta analysis
randomized controlled trial(RCT)
