摘要
肿瘤坏死因子受体相关因子4(tumor necrosis factor receptor-associated factor 4,TRAF4)是TRAFs(tumor necrosis factor receptor-associated factors)蛋白家族的成员之一,其作为信号转导的接头分子,具有E3泛素连接酶活性,可激活多种下游信号通路,在神经发生与胚胎发育、免疫调节与炎症反应、氧化损伤及代谢等多种生理过程中发挥着重要的调控作用。TRAF4在多种肿瘤中异常高表达,并调控肿瘤的发生发展。本文根据TRAF4的生理和病理调控功能,对TRAF4与肿瘤发生和发展的关系进行综述,为该基因在肿瘤治疗中的应用提供参考。
Tumor necrosis factor receptor-associated factor 4(TRAF4)is a member of the TRAF protein family.As a cytoplasmic linker molecule for signal transduction and a protein with E3 ubiquitin ligase activity,TRAF4 is closely associated with various physiological processes involved in embryonic development,immune and inflammatory responses,regulation of oxidative stress injury,and metabolism.TRAF4 is highly expressed in various tumors and regulates their occurrence and development.Based on the physiological and pathological functions of TRAF4,this paper reviews the relationship between TRAF4 and tumorigenesis and provides a reference for further research regardingthe application of this gene for tumor therapy.
作者
石翠娟
罗文君
于士柱
Cuijuan Shi;Wenjun Luo;Shizhu Yu(Department of Neuropathology,Tianjin Medical University General Hospital,Tianjin Neurological Institute,Tianjin Key Laboratory of Injuries;Variations and Regeneration of Nervous System,Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central;Nervous System(Ministry of Education),Tianjin 300052,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2023年第10期531-537,共7页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金项目(编号:81872061、81402050、81502166、81972354)
天津医科大学总医院“新世纪”人才培养计划项目资助。
关键词
TRAF4
信号通路
泛素连接酶
肿瘤发生
tumor necrosis factor receptor-associated factor 4(TRAF4)
signaling pathway
E3 ubiquitin ligase
tumorigenesis
